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Minerva Medica 2015 August;106(4 Suppl 3):9-16


lingua: Inglese

Emphysema: coiling up the lungs, trick or treat?

Bezzi M. 1, Mondoni M. 2, Sorino C. 3, 4, Solidoro P. 5

1 Centre Of Respiratory Endoscopy and Laser‑Theraphy, A.O. Spedali Civili di Brescia, Brescia, Italy; 2 Respiratory Unit, San Paolo Hospital, Milan, Italy; 3 Biomedical Depatment of Internal and Specialistic Medicine, University of Palermo, “Villa Sofia‑Cervello” Hospital, Palermo, Italy; 4 Pulmonology Unit, AO Sant’Anna, Como, Italy; 5 S.C. of Pneumology, Cardiovascular and Thoracic Department, A.O. Città della Salute e della Scienza di Torino, Turin, Italy


Lung volume reduction coil (LVRC) treatment is a minimally-invasive technique planned to achieve an improvement of exercise capacity and pulmonary function in subjects with advanced emphysema and hyperinflation. It has been proposed together with other bronchoscopic lung volume reduction approaches to reduce lung hyperinflation in emphysema as less invasive alternatives to LVRS and are currently under clinical investigation. Following the successful early experiences in previous pilot trials, recent studies allow further investigation into the feasibility, safety and efficacy of LVR coil treatment in a multi-center setting in a larger group of patients. According to this studies we can state that LVR coil treatment results in significant clinical improvements in patients with severe emphysema, in multicenter analysis, with a good safety profile and sustained results for up to 1 year. The literature on endobronchial coils continues to look promising with an acceptable safety profile, and positive long-term follow-up data are certainly more and more available. However, further well-designed, blinded, placebo (or sham) controlled trials, and even randomized trials against LVRS (lung volume reduction surgery), are needed before routine clinical use can be recommended. This is true not only for endobronchial coils, but also for the whole field of bronchoscopic lung volume reduction.

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