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Minerva Medica 2014 December;105(6 Suppl 2):1-8


lingua: Inglese

Effect of Liverubin™ on hepatic biochemical profile in patients of alcoholic liver disease: a retrospective study

Nanda V. 1, Gupta V. 2, Sharma S. N. 3, Pasricha A. 4, Kumar Karmakar A. 5, Patel A. 6, Bhatt V. M. 7, Kantroo B. L. 8, Kumar B. 9, Ketar Paul N. K. 10, Attam R. 11

1 Kidney Hospital and Lifeline Medical Institutions, Punjab, India; 2 Private Practitioner, Amritsar, India; 3 Private Practitioner, Pathsala, India; 4 Pasricha Medical Cardiac and Diabetes Clinic, New Delhi, India; 5 SSKM Hospital, Kolkata, India; 6 Aavkar Heart and Medical Hospital Himatnagar, India; 7 Gayatri Medicare,Himatnagar, India; 8 Private Practitioner, NewDelhi, India; 9 Private Practitioner, Patna, India; 10 KetaurPaul Hospital, Hisar, India; 11 Altah Hospital, New Delhi, India


Liverubin™ is an available drug in the Indian market that contains silymarin, the major active complex extracted from the medicinal plant milk thistle (Silybum marianum L.). The study retrospectively tracked and analyzed the data of 602 patients, out of which 230 were alcohol induced; 131 with alcohol-induced liver damage (ALD), 13 with liver cirrhosis, and 86 with fatty liver; to assess the effects of water soluble Silymarin (Liverubin™) on important hepatic biochemical parameters. The data was collected from 32 major cities treated by 72 physicians across India who were observed for the specified treatment duration of 11 months. Data was analyzed by using descriptive statistics. At the end of the treatment the hepatic biochemical profile was appreciably improved: the mean % of change in the levels of important hepatic biochemical parameters was observed as follows: total bilirubin 63.48% (direct bilirubin: 64.96%; indirect bilirubin: 61.63%). The serum SGOT and SGPT changed at a mean % of 65.43 and 69.31 respectively while serum alkaline phosphatase was changed at a mean % rate of 39.81. Liverubin™ proved to be safe & well-tolerated among the studied population and no significant treatment related adverse events were reported during the study. Liverubin™ treatment is found to bring about effective lowering of abnormally elevated hepatic biochemical parameters. Liverubin™, water soluble active Silymarin, in the popularly prescribed doses of 140-mg tid is observed to be a promising safe and effective drug in cases of alcoholic liver disease.

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