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Minerva Ginecologica 2020 Sep 14

DOI: 10.23736/S0026-4784.20.04615-8


lingua: Inglese

Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis. In vitro and in vivo studies

Mario FADIN 1, Maria Celeste NICOLETTI 2, Marzia PELLIZZATO 3, Manuela ACCARDI 1, Maria Grazia BAIETT 1I, Andrea FRATTER 4

1 Gynaecologist, Sempione Medical Centre, Milan, Italy; 2 Krea Innovazione srl, Milan, Italy; 3 Vice-President Italian Society of Nutraceutical Formulators, Castelfranco Veneto, Treviso, Italy; 4 Post-graduated in Clinical Pharmacology, President of the Italian Society of Nutraceutical Formulators, Castelfranco Veneto, Treviso, Italy


OBJECTIVE: To evaluate the efficacy of oral administration of a novel composition composed of Quercetin, Curcumin, Acetylcysteine in reducing pain in women affected by endometriosis, through the reduction of the inflammatory-hyperproliferative component of the ectopic endometrial tissue.
METHODS: 33 women with clinical diagnosis of endometriosis from at least 3 months have been enrolled. Patients have been treated daily with 200 mg of Quercetin, 210 mg of dry extract of Curcuma Longa (titrated at 95% in Curcuminoids) and 150 mg of Acetylcysteine (1 tablet of Alliendo) for 2 months. The overall symptomatology with specific reference to dysmenorrhea, pelvic pain and dyspareunia, together with the frequency of NSAID’s drugs assumption have been evaluated at the beginning and at the end of the treatment.
RESULTS: Overall, the results collected at the end of the treatment according to the parameters evaluated and above mentioned on the 33 patients enrolled, show a significative improvement in the reduction of pain symptoms associated to endometriosis (p<0,001 for dysmenorrhea, pelvic pain and dyspareunia). The use of NSAID’s together with an overall reduction of their dosage and time of assumption has been reduced as well. No significative side effects have been observed.
CONCLUSIONS: The aforementioned results suggest that administration of the composition described can represent a valuable adjuvant treatment in the reduction of pain symptomatology associated to endometriosis, triggered by inflammatory cascade and hyperproliferation of ectopic tissue.

KEY WORDS: Endometriosis; Quercetin; Curcumin; Acetylcystein; Alliendo

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