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Minerva Ginecologica 2018 Apr 11

DOI: 10.23736/S0026-4784.18.04231-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

From isolation of human ovarian follicles to the artificial ovary: tips and tricks

Maria C. CHITI 1, Jacques DONNEZ 2, Christiani ANDRADE AMORIM 1, Marie-Madeleine DOLMANS 1, 3

1 Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium; 2 Society for Research into Infertility, Brussels, Belgium; 3 Gynecology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium


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Cryopreservation and transplantation of ovarian tissue has proved to restore both endocrine and reproductive functions in cancer patients. However women with a high risk of ovarian involvement cannot undergo ovarian tissue transplantation due to possible recurrence of the disease. Therefore, different teams worldwide are now working on the development of experimental strategies, like the transplantable artificial ovary (TAO), with the noble goal to offer to these patients hope for future conception. This article discusses some essential points for the creation of a TAO and reviews the latest progress made.


KEY WORDS: Human ovarian follicle isolation - Artificial ovary - Fertility preservation

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Publication History

Article first published online: April 11, 2018
Manuscript accepted: April 4, 2018
Manuscript received: March 20, 2018

Per citare questo articolo

Chiti MC, Donnez J, Andrade Amorim C, Dolmans MM. From isolation of human ovarian follicles to the artificial ovary: tips and tricks. Minerva Ginecol 2018 Apr 11. DOI: 10.23736/S0026-4784.18.04231-4

Corresponding author e-mail

marie-madeleine.dolmans@uclouvain.be