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Minerva Ginecologica 2018 Apr 11

DOI: 10.23736/S0026-4784.18.04229-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Fertility preservation in women with ovarian endometriosis

Jacques DONNEZ 1 , Javier GARCÍA-SOLARES 2, Marie-Madeleine DOLMANS 3

1 Université Catholique de Louvain. Société de Recherche pour l'Infertilité, Brussels, Belgium; 2 Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale (IREC), Université Catholique de Louvain, Brussels, Belgium; 3 Gynecology Department, Cliniques Universitaires Saint Luc, Brussels, Belgium


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Endometriosis is a frequently encountered benign gynecological disease that may be responsible for infertility. Treatment of endometriosis-associated infertility has been investigated using both medical and surgical therapeutic modalities. Therapy has essentially three main objectives: (i) to preserve and improve fertility, (ii) to reduce pain, and (iii) to delay recurrence. The aim of this paper is to focus on fertility preservation in women with severe endometriosis. In ovarian endometriosis-associated infertility, a medico-surgical approach remains the gold standard, but more and more papers are reporting a low ovarian reserve after laparoscopic cystectomy for endometriomas. Indeed, very frequently, normal ovarian tissue is excised together with the endometrioma wall, even if surgery is performed by experienced surgeons. Vitrification of oocytes should thus be considered in all patients at serious risk of future fertility impairment, particularly in case of recurrence after surgery or before any treatment likely to result in premature ovarian insufficiency (POI). This paper also describes techniques of ovarian tissue cryopreservation (slow-freezing) and reimplantation, which should be considered in case of recurrence risk.


KEY WORDS: Fertility preservation - Ovarian endometriosis - Vitrification of oocytes - Cryopreservation of ovarian tissue - Combined technique

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Publication History

Article first published online: April 11, 2018
Manuscript accepted: April 4, 2018
Manuscript received: March 16, 2018

Per citare questo articolo

Donnez J, García-Solares J. Fertility preservation in women with ovarian endometriosis. Minerva Ginecol 2018 Apr 11. DOI: 10.23736/S0026-4784.18.04229-6

Corresponding author e-mail

acques.donnez@gmail.com