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Rivista di Ostetricia e Ginecologia

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index



Minerva Ginecologica 2017 Oct 09

DOI: 10.23736/S0026-4784.17.04131-4


lingua: Inglese

Urine protein to creatinine ratio: a point of care for the diagnosis of preeclampsia

Lior SALMON 1, Salvatore A. MASTROLIA 2 , Batel HAMOU 1, Renana WILKOF-SEGEV 3, Ruthy BEER-WEISEL 1, Vered KLAITMAN 1, Limor BESSER 1, Offer EREZ 1

1 Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; 2 Department of Maternal-Fetal Medicine, Fondazione MBBM, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy; 3 Clinical Research Center, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel


BACKGROUND: To determine the correlation between the urine protein-creatinine ratio (UPCR)and the 24h-UPET;and to identify the optimal threshold values of UPCR for the diagnosis of preeclampsia and its severe form.
METHODS: This prospective cohort study included 81 hypertensive pregnant patients who had a 24h-UPET and a UPCR tests. Two groups were created using a UPCR cut-off of 23.2mg/mmol[negative UPCR(n=40);positive UPCR(n=41)].
RESULTS: 1)49 patients of were diagnosed with preeclampsia, and 23 of them had a severe disease; 2)there was a significant correlation between UPCR and 24h-UPET; 3)a cut-off PUCR value of 23.2 mg/mmol had an area under the curve=0.927, sensitivity of 89%, specificity 88%, positive predictive value 90%, a positive likelihood ratio (+LR) of 7.41 and a negative likelihood ratio (-LR) of 0.13 for the diagnosis of preeclampsia;4)UPCR value of 325mg/mmol had an area under the curve=0.841, and a sensitivity of 83%,specificity 81%, positive predictive value 81%,+LR of 4.4 and -LR of 0.2 for the diagnosis of severe preeclampsia.
CONCLUSIONS: 1)the UPCR test is highly correlated with 24h-UPET;2)we propose a novel and sensitive cut-off for the diagnosis of preeclampsia by UPCR test;and 3)the UPCR test can be used for the identification of hypertensive patients with preeclampsia and severe disease.

KEY WORDS: Preeclampsia - Proteinuria - ROC curve analysis - 24 Hours urine proteine excretion test

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Publication History

Article first published online: October 9, 2017
Manuscript accepted: October 5, 2017
Manuscript received: August 12, 2017

Per citare questo articolo

Salmon L, Mastrolia SA, Hamou B, Wilkof-Segev R, Beer-Weisel R, Klaitman V, et al. Urine protein to creatinine ratio: a point of care for the diagnosis of preeclampsia. Minerva Ginecol 2017 Oct 09. DOI: 10.23736/S0026-4784.17.04131-4

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