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Minerva Ginecologica 2020 April;72(2):70-4

DOI: 10.23736/S0026-4784.20.04495-0

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Efficacy of food supplement Acidif plus® in the treatment of uncomplicated UTIs in women: a pilot observational study

Clorinda BARLETTA 1, Maria PACCONE 1 , Nadia UCCELLO 1, Lucrezia O. SCALDARELLA 1, Carmine ROMANO 1, Giampaolo MAININI 2, Mario PASSARO 2

1 ASL Caserta, Caserta, Italy; 2 ASL NA3 SUD, Naples, Italy



BACKGROUND: Urinary tract infections (UTIs) are among the most common bacterial infection diagnosed in women. The standard therapy is represented by short course of anti-microbial treatment to eradicate causative pathogens. However, due to antibiotic treatment, normal microbiota of the gastrointestinal tract is at risk of depletion and prolonged use of antibiotics can lead to the development of resistant strains. The aim of this pilot study was to assess the efficacy of Acidif plus®, a novel preparation containing L-Methionine, Boswellia serrata and Hibiscus sabdariffa, in the treatment of UTIs in women, in comparison with standard antibiotic treatment with fosfomycin.
METHODS: We performed a pilot clinical study with 88 patients with uncomplicated UTIs treated in ambulatory care clinics. The subjects recruited in the study were divided into two groups: the treatment group included 57 patients with both symptomatic and asymptomatic uncomplicated, bacteriuria-positive UTIs, who were treated by oral administration of Acidif plus® two tablets per day (1 tablet in the morning and 1 tablet in the evening) for 7 days. The control group included 31 patients with both symptomatic and asymptomatic bacteriuria-positive uncomplicated UTIs, treated with fosfomycin for two consecutive days. Clinical improvement of symptoms and urine bacteriuria were evaluated as treatment outcomes.
RESULTS: More than 50% of Acidif plus® treated patients were free of symptoms of UTIs at the end of the treatment regime. In addition, Acidif plus® treatment was effective in eliminating the bacterial infection in the post-treatment urine cultures in more than 85% of the patients.
CONCLUSIONS: In this study Acidif plus® treatment in patients with uncomplicated UTIs was found to be non-inferior to the standard antibiotic therapy. In acute setting, Acidif plus® was shown to be even more effective in alleviating the symptoms than fosfomycin and in eliminating bacteria in urine cultures. It is therefore possible to propose Acidif plus® as a potential alternative option to reduce the problem of multi-drug resistance in urinary infections.


KEY WORDS: Urinary tract infections; Phytotherapy; Methionine; Hibiscus; Boswellia

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