ORIGINAL ARTICLE   

Minerva Ginecologica 2017 October;69(5):405-12

DOI: 10.23736/S0026-4784.17.04028-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Outcome of endometrial cancer after lymphadenectomy: a single center retrospective analysis with long-lasting follow-up

Pantaleo GRECO ¹, Ruby MARTINELLO ¹, Ugo INDRACCOLO ², Chiara BORGHI ¹, Gloria BONACCORSI ¹, Gennaro SCUTIERO ¹ ✉

¹ Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Cona, Ferrara, Italy; ² Unit of Obstetrics and Gynecology, Alto Tevere Hospital of Città di Castello, Città di Castello, Perugia, Italy

BACKGROUND: Role of lymphadenectomy in endometrial cancer is unclear. Our objective is to assess the role of lymphadenectomy in endometrial cancer.
METHODS: The study reviewed retrospectively 829 cases of endometrial cancer from a single non-oncological center from 1981 to 2014. Multivariable Cox regression analyses were performed. Independent variables were: 2009 FIGO stage, histological type of endometrial cancer (non-endometrioid, endometrioid, grading 1, 2 and 3), radicality on parametria, lymphatic dissection (any kind) (yes/no), any kind of chemotherapy, any kind of radiotherapy, brachytherapy, patients’ age. Dependent variable was death for endometrial cancer and first relapse. Time variable was the semester of follow-up. P value for significance was set <0.05.
RESULTS: Many data about the extension of node dissection were missing. Pelvic node dissection or sampling seem the more common procedure performed. At the 10-semester of follow-up, at the 20-semester of follow-up and at the 30 semester of follow up, lymphadenectomy does not improve overall survival at a p value of less than 0.05. Lymphadenectomy reduces the risk of relapse at the 10 semester and 20-semester of follow-up.
CONCLUSIONS: Lymphadenectomy plays a role in preventing relapses but it is not proved that non-aggressive lymphadenectomy in endometrial cancer improves overall survival at p level of 0.05. Therefore, it cannot be excluded that a very small improvement in long lasting survival in few cases of endometrial cancer could be due to node dissections.

KEY WORDS: Endometrial neoplasms - Follow-up studies - Lymph node excision - Survival