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Rivista di Ostetricia e Ginecologia

Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index




Minerva Ginecologica 2017 April;69(2):141-9

DOI: 10.23736/S0026-4784.16.03946-0


lingua: Inglese

Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome

Charlotta KLEVEDAL, Sahruh TURKMEN

Department of Clinical Sciences, Obstetrics and Gynecology, Sundsvalls Research Unit, Umeå University, Umeå, Sweden


BACKGROUND: Earlier studies have shown that polycystic ovary syndrome (PCOS) is associated with cardiovascular disease as well as pregnancy complications. We examined whether women with PCOS have an increased risk of complications in pregnancy compared with healthy women, and if there are any correlations between complications and clinical/demographic variables before and/or in early pregnancy.
METHODS: This retrospective cohort study comprised 37 women with PCOS and 126 healthy women whose birth was recorded at Sundsvall County Hospital, Sweden, from 2009 to 2014. Medical records were searched to identify pregnancy complications, maternal outcomes, and neonatal outcomes.
RESULTS: Compared with healthy women, the women with PCOS were more likely to have a history of miscarriage (42.9% vs. 19.8% P=0.005) and undergo caesarean section (41.2% vs. 21.4%, P=0.019). They were also at increased risk of developing a complication (odds ratio 2.38, 95% CI: 1.05-5.38) or having multiple concurrent complications (odds ratio 8.27, 95% CI: 1.45-47.3). The rates of premature birth, birth weight and Apgar score at 5 min were similar between the two groups. The preconception serum testosterone concentration was positively correlated with the complication rate and negatively correlated with gestational age.
CONCLUSIONS: We found that women with PCOS are at greater risk of complications during pregnancy than healthy women, consistent with the results of earlier studies. High testosterone concentrations could be an aggravating factor in the risk of complications. Therefore, women with PCOS may require more careful monitoring during pregnancy than healthy women.

KEY WORDS: Body Mass Index - Polycystic ovary syndrome - Pregnancy outcome - Pregnancy complications - Retrospective studies - Testosterone

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Publication History

Issue published online: January 30, 2017
Article first published online: June 16, 2016
Manuscript accepted: June 10, 2016
Manuscript received: June 1, 2016

Per citare questo articolo

Klevedal C, Turkmen S. Fetal-maternal outcomes and complications in pregnant women with polycystic ovary syndrome. Minerva Ginecol 2017;69:141-9. DOI: 10.23736/S0026-4784.16.03946-0

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