Home > Riviste > Minerva Endocrinology > Fascicoli precedenti > Minerva Endocrinologica 2020 March;45(1) > Minerva Endocrinologica 2020 March;45(1):29-35

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

ORIGINAL ARTICLE   

Minerva Endocrinologica 2020 March;45(1):29-35

DOI: 10.23736/S0391-1977.18.02914-0

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Improving effect of vitamin D supplementation on obesity-related diabetes in rats

Yanfang GUO 1, Ling ZHU 1, Yi GE 1, Hao ZHANG 2

1 Department of Pediatrics, Gongli Hospital, Second Military Medical University, Shanghai, China; 2 Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China



BACKGROUND: Vitamin D, a fat-soluble secosteroid, plays a key role in several metabolic diseases like diabetes. Diabetes is becoming a third leading chronic disease in the world, which seriously threatens human health.
METHODS: In the current study, we found the beneficial effects of vitamin D supplementation in obesity-related diabetes rat. Enzyme-linked immunosorbent assay, biochemical testing, real-time PCR and western blot were carried to investigate the effect of vitamin D supplementation on diabetes.
RESULTS: Successful modeling of obesity-related diabetes was determined by significant weight loss and elevated levels of fasting blood glucose, glycated hemoglobin and blood lipids at 12 weeks. Supplementation of vitamin D obviously increased body weight and decreased fasting blood glucose, glycated hemoglobin, and blood lipids, accompanied by increased 25-hydroxyvitamin D and decreased insulin, parathormone and adipocytokines. Furthermore, low expressed insulin receptor substrate-1 (IRS-1)/phosphorylation of IRS-1 (p-IRS-1), glucose transporter type 4 (GluT4) and vitamin D receptor (VDR) was increased.
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation.


KEY WORDS: Insulin receptor substrate proteins; Streptozocin; Vitamin D

inizio pagina