ORIGINAL ARTICLE   

Minerva Endocrinologica 2018 June;43(2):101-8

DOI: 10.23736/S0391-1977.17.02595-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Role of adipokines and inflammatory markers in postmenopausal hypertension

Mose JULY ¹, Saba FAIZ ^{1, 2}, Abid YAQUB ^{1, 3}, Prasanna SANTHANAM ^{1, 4}, Jillian DOUGLAS ¹, Ronald STANEK ¹, Todd GRESS ⁵, Omolola OLAJIDE ¹, Henry DRISCOLL ¹, Nalini SANTANAM ⁶ ✉

¹ Department of Endocrinology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; ² Pennsylvania Institute of Endocrinology, Lititz, PA, USA; ³ Division of Endocrinology, University of Cincinnati College of Medicine, Cincinnati, OH, USA; ⁴ Department of Nuclear Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; ⁵ Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; ⁶ Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA

BACKGROUND: The role of inflammatory markers and adipokines contributing to the development of postmenopausal hypertension, has not been established. The aim of our study was to assess the complex association between blood pressure, obesity, menopausal status, adipokines and inflammatory mediators in postmenopausal women.
METHODS: We recruited 38 women seen at our Endocrinology Clinic and collected anthropometric measures and blood pressure and obtained serum samples for inflammatory markers and adipokine levels. Out of 38 women, 23 (60%) were postmenopausal.
RESULTS: In the pre-menopausal and postmenopausal women, there were no significant differences in measured adipokines and inflammatory markers based on hypertensive status. When obesity was eliminated, significantly higher levels of EGF, IL-8, MCP1 and TNF-α and lower levels of IL-1α and IL-3 were observed in the postmenopausal group (P<0.05). Women with higher waist-to-hip ratio (WHR) had a significant trend towards lower adiponectin levels as compared to those with lower WHR (P=0.014 and P=0.04, respectively).
CONCLUSIONS: There was a significant difference in pro-inflammatory markers in non-obese, pre- and post-menopausal women. These higher inflammatory markers might play a role in the development of post-menopausal hypertension.

KEY WORDS: Adiponectin - Biomarkers - Inflammation - Obesity - Waist-hip ratio