ORIGINAL ARTICLES   

Minerva Endocrinologica 2016 September;41(3):298-301

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Serum heart type fatty acid binding protein levels are not changed in hyperthyroidism

Mustafa OZBEK ¹, Askin GUNGUNES ¹, Mustafa SAHIN ², Zeynep GINIS ³, Bekir UCAN ¹, Muyesser SAYKI ¹, Esra TUTAL ¹, Erman CAKAL ¹, Şerife M. KUŞKONMAZ ⁴, Mehmet A. ÖZTÜRK ⁵, Tuncay DELIBASI ¹ ✉

¹ Department of Endocrinology and Metabolism, Diskapi Teaching and Research Hospital, Ankara, Turkey; ² Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey; ³ Department of Biochemistry, Diskapi Teaching and Research Hospital, Ankara, Turkey; ⁴ Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara Turkey; ⁵ Department of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey

BACKGROUND: Heart type fatty acid binding protein (H-FABP) is a small protein and released into the circulation when myocardial damage has occurred. Previous studies have demonstrated that H-FABP is closely associated with cardiac and some endocrinologic disorders including prediabetes, metabolic syndrome, and acromegaly. Hyperthyroism is a well-known disorder associated with cardiovascular diseases. We aimed to investigate the effect of hyperthyrodism on H-FABP levels.
METHODS: Forty six patients with hyperthyroidism with no known history of coronary artery disease and 40 healthy controls are involved in the study. Serum H-FABP levels are measured using sandwich enzyme-linked immunosorbent assay.
RESULTS: There was no significant difference between serum H-FABP levels of patients with hyperthyroidism and controls (871±66 pg/mL, and 816±66 pg/mL, respectively P=0.56). There was no significant correlation between H-FABP, free triiodothyronine (fT3), free thyroxine (fT4), and thyroid stimulating hormone (TSH) levels in patients and controls.
CONCLUSIONS: Serum H-FABP levels are not altered in patients with hyperthyroidism.