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Minerva Endocrinologica 2018 Feb 08

DOI: 10.23736/S0391-1977.18.02693-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Quality of semen: a 6-year single experience study on 5680 patients

Mauro COZZOLINO 1 , Maria E. COCCIA 1, Rita PICONE 1, Gianmarco TROIANO 2

1 Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital, Florence, Italy; 2 Post Graduate School of Public Health, University of Siena, Siena, Italy


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BACKGROUND: The aim of our study was to evaluate the quality of semen of a large sample from general healthy population living in Italy, in order to identify possible variables that could influence several parameters of spermiogram.
METHODS: We conducted a cross-sectional study from February 2010 to March 2015, collecting semen samples from the general population. Semen analysis was performed according to the WHO guidelines. The collected data were inserted in a database and processed using the software Stata 12. The Mann - Whitney test was used to assess the relationship of dichotomus variables with the parameters of the spermiogram; Kruskal-Wallis test for variables with more than two categories. We used also Robust regression and Spearman correlation to analyze the relationship between age and the parameters.
RESULTS: We collected 5680 samples of semen. The mean age of our patients was 41.4 years old. Mann-Whitney test showed that the citizenship (codified as “Italian/Foreign”) influences some parameters: pH, vitality, number of spermatozoa, sperm concentration, with worse results for the Italian group. Kruskal-Wallis test showed that the single nationality influences pH, volume, Sperm motility A-B-C-D, vitality, morphology, number of spermatozoa, sperm concentration. Robust regression showed a relationship between age and several parameters: volume (p=0.04, R squared= 0.0007 β: - 0.06); sperm motility A (p<0.01; R squared 0.0051 β: 0.02); sperm motility B (p<0.01; R squared 0.02 β: -0.35); sperm motility C (p<0.01; R squared 0.01 β: 0.12); sperm motility D (p<0.01; R squared 0.006 β: 0.2); vitality (p<0.01; R squared 0.01 β: -0.32); sperm concentration (p=0.01; R squared 0.001 β: 0.19).
CONCLUSIONS: Our patients had spermiogram’s results quite better than the standard guidelines. Our study showed that the country of origin could be a factor influencing several parameters of the spermiogram in healthy population and through Robust regression confirmed a strict correlation between age and these parameters.


KEY WORDS: Semen quality - Infertility - Male factors - Oligozoospermia - Asthenozoospermia

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Publication History

Article first published online: February 8, 2018
Manuscript accepted: February 1, 2018
Manuscript received: June 27, 2017

Per citare questo articolo

Cozzolino M, Coccia ME, Picone R, Troiano G. Quality of semen: a 6-year single experience study on 5680 patients. Minerva Endocrinol 2018 Feb 08. DOI: 10.23736/S0391-1977.18.02693-7

Corresponding author e-mail

maurocoz@yahoo.it