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Minerva Endocrinologica 2019 March;44(1):91-6

DOI: 10.23736/S0391-1977.18.02734-7

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy

Wenchen GUO 1, Hongyan WANG 2, Qi LIU 3, Yuchao YUAN 4, Yanyan JING 2, Xiaoju YANG 5

1 Department of Clinical Laboratory, People’s Hospital of Weifang, Weifang, China; 2 Department of Obstetrics, People’s Hospital of Zhangqiu Distric, Jinan, China; 3 Department of Endocrinology, People’s Hospital of Zhangqiu Distric, Jinan, China; 4 Department of Obstetrics and Gynecology, People’s Hospital of Zhangqiu Distric, Jinan, China; 5 Department of Obstetrics and Gynecology, East Hospital of Tongji University, Shanghai, China



BACKGROUND: The aim of this study was to investigate the relationship of serum iron and ferritin concentrations in early pregnancy with gestational diabetes mellitus (GDM) complicated in pregnant metaphase through detecting the serum iron and ferritin concentrations in early pregnancy of normal pregnant women, so as to provide new ideas for the early detection and prevention of GDM.
METHODS: Spontaneously pregnant women with single fetus receiving prenatal routine examination in our hospital from December 2014 to October 2016 were selected. They were in good health before with normal fasting blood-glucose in early pregnancy without anemia during pregnancy and any medication history. The serum iron and ferritin concentrations were measured at 12 gestational weeks, the fasting blood-glucose was detected at 12 weeks of pregnancy, and 75g oral glucose tolerance test was performed at 24-26 weeks. According to the results of oral glucose tolerance test, the pregnant women were divided into GDM group (N.=52) and normal control group (N.=310). The detection results of pregnant women in the two groups were statistically analyzed.
RESULTS: The serum ferritin and iron levels at 12 gestational weeks in GDM group were higher than those in normal pregnancy group (P<0.05). The cut-off values of serum ferritin and iron at 12 gestational weeks in the prediction of GDM were 67.8 μg/L and 52.9 mmol/L.
CONCLUSIONS: The high concentrations of serum iron and ferritin in early pregnancy have a certain correlation with the incidence of GDM, and the early detection of serum iron and ferritin levels can improve the detection rate of GDM in pregnant metaphase.


KEY WORDS: Iron - Ferritins - Diabetes, gestational

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