ORIGINAL ARTICLE   

Minerva Endocrinologica 2018 September;43(3):253-8

DOI: 10.23736/S0391-1977.17.02721-3

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Expression and clinical significance of EGF and TGF-α in chronic pancreatitis and pancreatic cancer

Chengfei HAO, Zhonglian LI ✉, Xibo ZHANG, Hongtao ZHANG, Haitao SHANG, Jianheng BAO, Haibo WANG

Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin, China

BACKGROUND: The purpose of this project was to investigate the expression and clinical significance of epidermal growth factor (EGF) and the transforming growth factor-α (TGF-α) in the occurrence and development of chronic pancreatitis and pancreatic cancer.
METHODS: We recruited 31 patients with chronic pancreatitis, 42 with pancreatic cancer, and 20 with normal pancreas in our hospital. Chronic pancreatitis, pancreatic cancer, and normal pancreas expressed EGF and TGF-α mRNAs as well as EGF and TGF-α proteins.
RESULTS: Immunofluorescence showed that EGF and TGF-α were expressed in chronic pancreatitis and pancreatic cancer, but the expression levels for both proteins were higher in pancreatic cancer. Variance analysis indicated that the differences in the expression levels of EGF and TGF-α in chronic pancreatitis, pancreatic cancer, and normal pancreas were statistically significant. The abnormally elevated expression of EGF and TGF-α are closely associated with the occurrence and development of chronic pancreatitis and pancreatic cancer.
CONCLUSIONS: EGF and TGF-α have important research value as indicators to assess the progression of these conditions and provide a new basis for the clinical diagnosis.

KEY WORDS: Epidermal growth factor - Transforming growth factor alpha - Pancreatitis, chronic - Pancreatic neoplasms