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Minerva Endocrinologica 2017 March;42(1):1-7

DOI: 10.23736/S0391-1977.16.02561-X

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Hypertriglyceridemic waist in type 1 diabetes patients: prevalence and related factors

Mercè FERNÁNDEZ-MIRÓ 1, 2, Juan J. CHILLARÓN 2, 3, 4 , Mercè ALBAREDA 5, Sara FONTSERÈ 2, 6, Cristina COLOM 1, Lluís VILA 5, Juan PEDRO-BOTET 2, 3, 4, Juana A. FLORES LE-ROUX 2, 3, 4, on behalf of TEST-T1D study group 

1 Department of Internal Medicine-Endocrinology and Nutrition, Centre d’Atenció Integral Dos de Maig, Barcelona, Spain; 2 Department of Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain; 3 Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; 4 IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; 5 Department of Endocrinology and Nutrition, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí, Spain; 6 Department of Medicine, Universitat Pompeu Fabra, Barcelona, Spain


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BACKGROUND: The hypertriglyceridemic waist has been linked to a higher number of cardiovascular risk factors and a greater probability of developing diabetes and cardiovascular disease. Around 50% of individuals with type 1 diabetes (T1D) are overweight or obese and triglyceridemia is associated with the onset of micro- and macrovascular complications.
METHODS: A cross-sectional study was conducted in men with T1D to assess the association between the prevalence of hypertriglyceridemic waist and cardiovascular risk factors and hypogonadism. Triglyceride levels + abdominal circumference taken together were stratified into quartiles to identify the hypertriglyceridemic waist phenotype.
RESULTS: One hundred and eighty-one male patients were included. An increased prevalence of hypogonadism and hypertension in parallel to increased triglyceride + waist circumference quartile was observed. Patients in the highest quartile had higher insulin resistance measured by estimated glucose disposal rate (eGDR 7.8±2.1 mg/kg-1.min-1 in 1st quartile vs. 5.8±1.8 mg/kg-1.min-1 in 4th quartile, P=0.000), insulin requirements, hip circumference, percentage of fat mass, glycosilated hemoglobin and total and LDL cholesterol as well as lower levels of total testosterone (27.24±9.3 nmol/L in 1st quartile vs. 17.4±8 nmol/L in 4th quartile, P=0.000) and HDL cholesterol. An inverse relationship was found between triglycerides + waist circumference and total testosterone levels (R=-0.367, P<0.0001).
CONCLUSIONS: The hypertriglyceridemic waist in men with T1D is associated with an atherogenic lipid profile, hypertension, worse metabolic diabetes control, increased insulin resistance and a higher prevalence of hypogonadism.


KEY WORDS: Hypertriglyceridemic waist - Diabetes mellitus, type 1 - Metabolic syndrome X

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