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Minerva Dental and Oral Science 2022 Feb 04

DOI: 10.23736/S2724-6329.22.04425-4

Copyright © 2022 EDIZIONI MINERVA MEDICA

lingua: Inglese

Evaluation of gingival crevicular fluid interleukin - 35 as a marker for identification of periodontal disease activity

Kaustubh S. THAKARE 1 , Priti A. CHARDE 2, Manohar L. BHONGADE 2, Priyanka P. JAISWAL 2, Pawan S. BAJAJ 2

1 Department of Periodontology and implantology, V Y W S Dental College, Amravati, Maharashtra, India; 2 Department of Periodontology & Implantology, Sharad Pawar Dental College and Hospital, Wardha, Maharastra, India


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BACKGROUND: This study was carried out to evaluate and compare the levels of IL-35 in gingival crevicular fluid (GCF) in periodiontally healthy subjects, patients with gingivitis and chronic periodontitis and to assess IL-35 as a marker for identification of periodontal disease activity.
MATERIALS AND METHODS: GCF samples were obtained from periodontally healthy subjects (n = 15), gingivitis patients (n = 15) and patients with chronic periodontitis (n = 15). Clinical measurements like probing pocket depth, clinical attachment loss, bleeding on probing, papillary bleeding index, and modified plaque index were recorded. Enzyme-linked immunosorbent assay was used for the determination of GCF IL-35 levels in samples.
RESULTS: The IL-35 levels were significantly higher in the healthy subjects as compared to gingivitis and chronic periodontitis group. There was variation in GCF IL-35 levels in healthy sites in each group and gingivitis sites in gingivitis and chronic periodontitis patients.
CONCLUSIONS: The levels of IL-35 were observed to decrease with increase in the inflammatory status, so it might play a role in suppressing gingival inflammation and maintaining periodontal health.


KEY WORDS: Enzyme-linked immunosorbent assay; Gingival crevicular fluid; Gingivitis; Interleukin-35; Periodontitis

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