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ORIGINAL ARTICLE   Free accessfree

Minerva Stomatologica 2019 August;68(4):168-76

DOI: 10.23736/S0026-4970.19.04149-9


lingua: Inglese

Detection of peri-implant inflammation by the use of a matrix metalloproteinase-8 chair-side test

Saturnino M. LUPI 1 , Lucia REDOGLIA 1, Arianna RODRIGUEZ Y BAENA 2, Giorgia GARBELLI 1, Ruggero RODRIGUEZ Y BAENA 1

1 School of Dentistry, Department of Clinico-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; 2 Unit of Oral Surgery, Dental School, Department of Dentistry, San Raffaele Hospital IRCSS, Vita Salute University, Milan, Italy

BACKGROUND: Active matrix metalloproteinase-8 (MMP-8) enzymes are associated with inflammation and the degradation of implant-supporting tissues. A high concentration of these enzymes in the peri-implant sulcular fluid (PISF) has been associated with a pathological condition. The aim of the present study was to evaluate the ability of a chair-side MMP-8 test to individuate pathological peri-implant site. The working hypothesis is that positive response to MMP-8 test corresponds to pathological values of periodontal indexes. A secondary working hypothesis is that PISF sampling method influences the test accuracy.
METHODS: Fifty implants from 50 patients were evaluated during scheduled follow-up appointments in a clinical setting using the MMP-8 chair-side test and periodontal indices (probing depth, bleeding on probing, plaque index and peri-implant inflammation index). Two methods of PISF sampling were tested.
RESULTS: The MMP-8 test demonstrated significant diagnostic capacity and good sensitivity and accuracy regarding indices of bleeding on probing, plaque index, and peri-implant inflammation index but fair agreement.
CONCLUSIONS: Further studies should be performed to better define the interpretation of the MMP-8 chair-test results and their correlation to peri-implant indexes.

KEY WORDS: Early diagnosis; Matrix metalloproteinase-8; Peri-implantitis; Mucositis

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