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Minerva Chirurgica 2018 Mar 28

DOI: 10.23736/S0026-4733.18.07729-5


lingua: Inglese

DCIS management in the modern era

Ayesha KHAN 1 , Dorin DUMITRU 1, Giuseppe CATANUTO 2, 3, Nicola ROCCO 3, 4, Maurizio B. NAVA 3, 5, John BENSON 1, 6

1 Cambridge University Hospitals, NHS Foundation Trust, Cambridge, UK; 2 Multidisciplinary Breast Unit, Azienda Ospedaliera Cannizzaro, Catania, Italy; 3 G.RE.T.A. Group for Recontructive and Therapeutic Advancements, Milan, Naples, Catania, Italy; 4 Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Naples, Italy; 5 Department of Plastic Surgery, University of Milan, Milan, Italy; 6 School of Medicine, Anglia Ruskin University, Cambridge, UK


Ductal carcinoma in situ (DCIS) has been the subject of much controversy since the advent of population based breast screening programmes. An increasing number of asymptomatic women are being diagnosed with this condition and there is uncertainty over the best treatment algorithm for this condition if treatment is to be considered at all. Different subtypes of DCIS show innate differences in developmental pathways and biological behaviour. This is not only determined by pathological subtypes but there is increasing understanding of molecular biomarkers related to DCIS progression. The ultimate management aim is to identify a subgroup of patients in whom DCIS will not progress to invasive disease such that they can avoid morbidity from surgical and adjuvant therapies. This has to be balanced by the potential risk of undertreatment of patients in whom DCIS is likely to progress to invasive cancer and hence a reduced life expectancy. Results of current ongoing prospective randomised trials assessing the safety of omitting surgery for what is considered to be low risk DCIS are eagerly awaited for by patients and clinicians. However the definition of what is considered to be “low risk” DCIS is still to be ascertained.

KEY WORDS: Ductal carcinoma in situ - Breast surgery - Breast cancer

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Publication History

Article first published online: March 28, 2018
Manuscript accepted: March 19, 2018
Manuscript received: March 16, 2018

Per citare questo articolo

Khan A, Dumitru D, Catanuto G, Rocco N, Nava MB, Benson J. DCIS management in the modern era. Minerva Chir 2018 Mar 28. DOI: 10.23736/S0026-4733.18.07729-5

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