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Minerva Chirurgica 2017 February;72(1):24-30

DOI: 10.23736/S0026-4733.16.07212-6

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Fasting and post-prandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass

Jolanta A. DARDZIŃSKA 1, Łukasz KASKA 2, Piotr WIŚNIEWSKI 2, Ewa ALEKSANDROWICZ-WRONA 1, Sylwia MAŁGORZEWICZ 1

1 Department of Clinical Nutrition, Medical University of Gdańsk, Gdańsk, Poland; 2 Department of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Gdańsk, Poland


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BACKGROUNDː The mechanisms underlying the metabolic effect of surgical treatment for morbid obesity are still unclear. Furthermore, the hormonal and metabolic response to the promising and less-invasive version of Roux-en-Y gastric bypass (RYGB), i.e. mini gastric bypass (MGB), is poorly known. The aim of this study was to evaluate pre- and postprandial changes in peptide YY (PYY) and metabolic parameters in obese patients without diabetes and cardiovascular complications treated by both versions of gastric bypass.
METHODSː Venous blood for PYY and other assays was collected three months before and six months after bariatric operation (MGB and RYGB), in the fasting state and two hours after the consumption of a standard 300-kcal mixed meal (Nutridrink Standard, Nutricia Advanced Medical Nutrition, part of the Danone company, Schiphol, The Netherlands).
RESULTSː In the MGB group, elevated concentrations of the PYY has been detected both fasting and postprandially. The effect of the MGB on the PYY levels did not differ from the RYGB group outcomes.
CONCLUSIONSː The results of our study suggest similar endocrine and metabolic effects of MGB and RYGB procedures. Long-term efficacy and metabolic benefits of MGB require further research.


KEY WORDS: Peptide YY - Postprandial period - Obesity - Bariatric surgery - Gastric bypass

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Publication History

Issue published online: January 18, 2017
Article first published online: October 27, 2016
Manuscript accepted: October 19, 2016
Manuscript received: October 5, 2016

Per citare questo articolo

Dardzińska JA, Kaska Ł, Wiśniewski P, Aleksandrowicz-Wrona E, Małgorzewicz S. Fasting and postprandial peptide YY levels in obese patients before and after mini versus Roux-en-Y gastric bypass. Minerva Chir 2017;72:24-30. DOI: 10.23736/S0026-4733.16.07212-6

Corresponding author e-mail

annadar@gumed.edu.pl