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Minerva Cardiology and Angiology 2022 August;70(4):459-67

DOI: 10.23736/S2724-5683.21.05834-8


lingua: Inglese

Nano-crush technique in narrow-angle (<70°) bifurcation: bench test, CT reconstruction, fluid dynamics, and clinical outcomes

Shuvanan RAY 1 , Siddhartha BANDYOPADHYAY 1, Prithwiraj BHATTACHARJEE 1, Priyam MUKHERJEE 1, Suman KARMAKAR 1, Pallab K. BOSE 1, Sabyasachi MITRA 1, Anirban DALUI 2, Sayak RAY 3

1 Department of Cardiology, Fortis Hospital Anandapur, Kolkata, India; 2 Department of Community Medicine, R.G. Kar Medical College and Hospital, Kolkata, India; 3 Department of Mechanical Engineering, Indian Institute of Thechnology, Kharagpur, India

BACKGROUND: Bifurcation stenting techniques are still refining and under testing. Nano-crush is a novel technique which allow minimum protrusion of side branch struts at the ostium. To demonstrate the efficacy of Nano-crush technique in narrow-angle bifurcation (<70°) using bench test model, 3D reconstruction of the stent structure, computational fluid dynamics study and a clinical follow-up.
METHODS: This was a retrospective observational single-center study which included 40 patients who underwent angioplasty using Nano-crush technique for de-novo complex coronary bifurcation lesions with narrow bifurcation angle (<70°) between April˗2016 to March˗2019. The in-vitro bench test and computational fluid dynamics analysis were performed using a bifurcation model designed. The clinical primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiac death, myocardial infarction, and target lesion revascularization (TLR) at one-year angiographic follow-up.
RESULTS: The reconstructed results of in-vitro bench test showed minimum length of stent struts moving away from the rounded side branch ostium. The mean age of patients was 62.8±7.98 years (32 male) and presented 100% procedural success. The mean bifurcation angle was 47.3±9.2°. The MACE was reported in four (10%) patients which included one (2.5%) death and three (7.5%) TLR at the mean follow-up of 35.54±12.31 months. No significant correlation between occurrence of MACE and gender, age, comorbidities and bifurcation angle was reported.
CONCLUSIONS: The Nano-crush technique demonstrated least metal load around carina and abnormal flow dynamics in narrow angle (<70°) bifurcation lesions and also reported favorable long-term clinical outcomes.

KEY WORDS: Coronary artery disease; Percutaneous coronary intervention; Stents

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