REVIEW  INTERVENTIONAL IMAGING 

Minerva Cardiology and Angiology 2021 December;69(6):655-70

DOI: 10.23736/S2724-5683.21.05532-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Multi-modality intravascular imaging for guiding coronary intervention and assessing coronary atheroma: the Novasight Hybrid IVUS-OCT system

Retesh BAJAJ ^{1, 2}, Hector M. GARCIA-GARCIA ³, Brian K. COURTNEY ^{4, 5}, Anantharaman RAMASAMY ^{1, 2}, Vincenzo TUFARO ^{1, 2}, Emrah ERDOGAN ^{1, 2}, Ameer H. KHAN ^{1, 2}, Natasha ALVES ⁴, Krishnaraj S. RATHOD ^{1, 2}, Yoshinobu ONUMA ⁶, Patrick W. SERRUYS ^{6, 7}, Anthony MATHUR ^{1, 2}, Andreas BAUMBACH ^{1, 2}, Christos V. BOURANTAS ^{1, 2} ✉

¹ Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, UK; ² Cardiovascular Devices Hub, Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University, London, UK; ³ MedStar Washington Hospital Center, Washington, DC, USA; ⁴ Sunnybrook Research Institute, Schulich Heart Program, University of Toronto, Toronto, ON, Canada; ⁵ Conavi Medical, North York, ON, Canada; ⁶ School of Medicine, National University of Ireland Galway, Galway, Ireland; ⁷ National Heart and Lung Institute, Imperial College London, London, UK

Intravascular imaging has evolved alongside interventional cardiology as an adjunctive tool for assessing plaque pathology and for guiding and optimizing percutaneous coronary intervention (PCI) in challenging lesions. The two modalities which have dominated the field are intravascular ultrasound (IVUS), which relies on sound waves and optical coherence tomography (OCT), relying on light waves. These approaches however have limited efficacy in assessing plaque morphology and vulnerability that are essential for guiding PCI in complex lesions and identifying patient at risk that will benefit from emerging therapies targeting plaque evolution. These limitations are complementary and, in this context, it has been recognized and demonstrated in multi-modality studies that the concurrent use of IVUS and OCT can help overcome these deficits enabling a more complete and accurate plaque assessment. The Conavi Novasight Hybrid IVUS-OCT catheter is the first commercially available device that is capable of invasive clinical coronary assessment with simultaneously acquired and co-registered IVUS and OCT imaging. It represents a significant evolution in the field and is expected to have broad application in clinical practice and research. In this review article we present the limitations of standalone intravascular imaging techniques, summarize the data supporting the value of multimodality imaging in clinical practice and research, describe the Novasight Hybrid IVUS-OCT system and highlight the potential utility of this technology in coronary intervention and in the study of atherosclerosis.

KEY WORDS: Interventional ultrasonography; Optical coherence tomography; Endovascular procedures