ORIGINAL ARTICLE   

Minerva Cardioangiologica 2017 February;65(1):8-15

DOI: 10.23736/S0026-4725.16.04093-7

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Association between omentin and echo parameters in patients with chronic heart failure

Haiying JIANG ¹, Guangxian ZHAO ², Xiang LI ², Hongyan JIN ², Guang YANG ², Kuiyue JIN ², Limei PIAO ², Enbo ZHU ², Yanna LEI ², Ennan FANG ², Xiongyi HAN ², Yongshan NAN ³, Qinghua JIN ¹, Xianwu CHENG ⁴ ✉

¹ Department of Physiology and Pathophysiology, Yanbian University College of Medicine, Yanbian University, Yanji, China; ² Department of Cardiology, Yanbian University Hospital, Yanji, China; ³ Department of Anesthesiology, Yanbian University Hospital, Yanji, China

BACKGROUND: Adipose-derived adipokines have been demonstrated to be associated with the development of experimental heart disease through chronic inflammation and cardiac cell apoptosis. Omentin is to be one of the novel adipokines. The aim of this study is to investigate the relationship between circulating omentin and cardiac dysfunction in patients with chronic heart failure (CHF).
METHODS: A total of 189 CHF patients were studied, determining serum omentin and echocardiographic parameters. All participants were divided into two experimental groups: the 111 patients who had a left ventricular ejection fraction (EF) ≥40% (EF-H) and the 78 patients exhibiting EF values <40% (EF-L).
RESULTS: The EF-L group showed significantly higher circulating omentin levels compared to the EF-H group (210.8±67.2 vs. 155.3±45.3, P<0.001; Student’s t-test). Overall, the data of the linear regression analysis revealed that serum omentin levels correlated positively with left atrial diameters (r=0.31, P=0.006), left ventricular end-systolic dimensions (r=0.42, P<0.001), and left ventricular end-diastolic dimensions (r=0.38, P=0.002) and negatively with left ventricular EF (r=-0.45, P=0.001; Spearmen’s rank correlations coefficients for each). The multiple regression model included all variables at p<0.1 by the univariate analysis. A multiple logistic regression analysis demonstrated that high levels of patients’ serum omentin were associated with cardiac dysfunction in patients with CHF (OR=1.22; 95% CI: 0.91-1.58; P=0.009).
CONCLUSIONS: These findings suggested that elevated serum omentin levels were only very mildly related to the changes in cardiac volume and function in CHF patients. Further studies are then needed to assess the real clinical value of omentin in this setting.

KEY WORDS: Human ITLN 1 protein - Congenital heart defects - Heart failure - Biomarkers