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MINERVA CARDIOANGIOLOGICA

Rivista sulle Malattie del Cuore e dei Vasi


Official Journal of the Italian Society of Angiology and Vascular Pathology
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Cardioangiologica 2018 Mar 28

DOI: 10.23736/S0026-4725.18.04670-4

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Tricuspid valve regurgitation: epidemiology and pathophysiology

Yan TOPILSKY

Division of Cardiology, Tel Aviv Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel


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Compared with the vast literature concerning the prevalence, pathophysiology, and outcome of left valvular disease, the data concerning tricuspid regurgitation (TR) is very limited. In this review we summarized the present data concerning these important issues. We show that TR is as prevalent as aortic stenosis in the community, with increasing prevalence with age, and much more common in women. We review the present knowledge concerning the pathogenesis of TR, focusing on functional TR. We show that functional TR is multifactorial, resulting from both RV remodeling and pulmonary hypertension, and/or atrial fibrillation resulting in right atrial dilatation. We demonstrate that RV remodeling, mostly in the mid segment, will result in tethering. On the other side, right atrial remodeling will results mostly in pure annular dilatation and loss of valvular/annular coverage reserve. Finally, due to the heterogeneous nature of TR we review the outcome data for each presentation of TR, and show that in most contexts TR is associated with very poor outcome, even when adjusted for left ventricular systolic, and diastolic function, pulmonary pressure, and RV dysfunction.


KEY WORDS: Tricuspid regurgitation - Tethering - Annular dilatation - Prevalence - Outcome

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Publication History

Article first published online: March 28, 2018
Manuscript accepted: March 16, 2018
Manuscript received: March 13, 2018

Per citare questo articolo

Topilsky Y. Tricuspid valve regurgitation: epidemiology and pathophysiology. Minerva Cardioangiol 2018 Mar 28. DOI: 10.23736/S0026-4725.18.04670-4

Corresponding author e-mail

topilskyyan@gmail.com