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Minerva Cardioangiologica 2016 Apr 27


lingua: Inglese

Galectin-3 in patients with chronic heart failure: association with oxidative stress, inflammation, renal dysfunction and prognosis

Elena MEDVEDEVA 1, Ivan BEREZIN 1, Elena SURKOVA 1, 2, Dmitry YARANOV 3, Yuri SHCHUKIN 1

1 Department of Cardiology, Samara State Medical University, Samara, Russian Federation; 2 Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy; 3 Department of Internal Medicine, Danbury Hospital, Danbury, CT, USA


BACKGROUND: Galectin-3 is a recently developed biomarker of fibrosis, which may play a role in cardiac remodeling and associated with both the progression and severity of heart failure.
METHODS: A prospective cohort study of 190 patients with documented prior myocardial infarction and chronic HF (NYHA class II-IV) was conducted. Patients were divided into 3 groups based on their NYHA functional class. Levels of galectin-3, NT-proBNP, CRP, IL-6, oxidized-LDL, extracellular superoxide dismutase (EC-SOD), 3-nitrotyrosine, SH-groups, cystatin-C were determined. Follow-up period was 26 months, and all-cause mortality was determined as the primary end-point. Statistical analysis was performed and statistical significance was set at p<0.05.
RESULTS: The cytokines hs-CRP, IL-6 and markers of oxidative stress had significant positive correlation with plasma galectin-3 levels in all groups of patients. The level of galectin-3 was significantly different between the groups (p <0.05). Galectin-3 was found to be the most sensitive and specific value in determination of 26 months mortality in patients with chronic HF. Logistic regression analysis showed that age, galectin-3 and cystatin-C were associated with death during the follow up period.
CONCLUSIONS: Galectin-3 levels are elevated in patients with chronic HF across all NYHA functional classes. Galectin-3 shows positive correlation with markers of oxidative stress, inflammation and kidney dysfunction. Galectin-3 levels and cystatin-C levels are independent predictors of 26-month mortality in patients with chronic HF. Patients with cystatin-C level > 2800 pg/ml carry a worse prognosis. Galectin-3 level > 21 ng/ml associated with increased mortality.

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