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Minerva Cardioangiologica 2020 June;68(3):203-8

DOI: 10.23736/S0026-4725.19.05028-X

Copyright © 2019 EDIZIONI MINERVA MEDICA

lingua: Inglese

Hangover and fatigue: effects of Robuvit® supplementation. A pilot registry study

Shu HU 1, 2, Gianni BELCARO 1, 2 , Maria R. CESARONE 1, 2, Claudia SCIPIONE 1, 2, Valeria SCIPIONE 1, 2, Morio HOSOI 1, 2, Umberto CORNELLI 1, 2, Luciano PELLEGRINI 1, 2, Mark DUGALL 1, 2, Beatrice FERAGALLI 1, 2, Roberto COTELLESE 1, 2

1 Irvine3 Labs, Department of Medical and Oral Sciences and Biotechnologies, Chieti-Pescara University, Pescara, Italy; 2 International Agency for Pharma-Standard Supplements (IA-PSS), Pescara, Italy



BACKGROUND: The aim of this open registry study was to evaluate the effects of Robuvit® in subjects with hangover after acute alcohol consumption also measuring changes in levels of oxidative stress. A group using standard management (SM) and a group using SM and Robuvit® 300 mg/day for 3 days were compared.
METHODS: Nineteen male subjects with hangover were included in the SM group and 22 in the Robuvit® + SM group.
RESULTS: The groups were comparable at baseline. No side effects were observed. Fatigue scores - as the main observable symptom in these subjects, in both groups - were significantly lower in the group using Robuvit® (P<0.05) than in the control group after 24 hours. The scores of other symptoms like weakness, thirst, headache, muscle aches and body pain were significantly lower at 24 hours (P<0.05) with the supplement than in the control group. The scores of residual gastrointestinal symptoms (nausea, vomiting and stomach pain) were also significantly lower at 24 hours with Robuvit® (P<0.05). Sleep and rest were significantly better with Robuvit® (P<0.05). Sensory symptoms and cognitive functions were also significantly better with supplementation in comparison with SM only (P<0.05). Finally, scores of mood, concentration, depression, anxiety, irritability were significantly lower (P<0.05) with Robuvit® though these symptoms need a more specific and complete evaluation. Signs of sympathetic activity, tremor, sweating, increased heart rate improved significantly better with the supplement at 24 hours (P<0.05). Oxidative stress was increased at inclusion in all subjects; in the Robuvit® group, oxidative stress decreased significantly (P<0.05) at 24 hours; in controls (SM) oxidative stress showed minimal changes at 24 hours and it remained elevated above normal values (>330 CU). Most symptoms almost disappeared at 24 hours in the Robuvit® group. Significant symptoms were still observed in 11 out of 19 subjects in the SM group in comparison with four of 22 subjects using the supplementation with Robuvit® (P<0.05). Blood tests were normal in all subjects (hematocrit and kidney and liver functional test at 24 hours).
CONCLUSIONS: In conclusion, Robuvit® supplementation appears to improve hangover and relieved symptoms faster. More studies are needed to confirm this association between acute alcohol consumption and a possible hepatic dysfunction.


KEY WORDS: Robuvit; Fatigue; Oxidative stress

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