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Minerva Cardioangiologica 2020 April;68(2):126-33

DOI: 10.23736/S0026-4725.20.05096-3

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Predictors of procedural and clinical outcome in rotational atherectomy: analysis of a single center registry

Simone PERSAMPIERI , Stefano LUCREZIOTTI, Diego SALERNO-URIARTE, Lucia BARBIERI, Carlo SPONZILLI, Federica VALLI, Marco CENTOLA, Diego CASTINI, Stefano CARUGO

Operative Unit of Cardiology and Cardiological Intensive Therapy, San Paolo Hospital, Milan, Italy



BACKGROUND: Heavy calcified lesions can decrease effectiveness of drug eluted stents in preventing restenosis. Rotational atherectomy (RA) demonstrated to improve outcomes in patients with severely calcified lesions pretreated with debulking. However, its feasibility and its safety are continuously on stage. Our aim has been to identify predictors of clinical and procedural outcome in RA.
METHODS: We retrospectively analyzed a population of patients referred to our cath lab for urgent or elective coronary catheterization treated with RA. The associations between clinical variables and clinical or procedural events were evaluated using logistic regression. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE) from procedure date to last day of follow-up. MACE have been defined as follows: cardiovascular death, heart failure hospitalization and target lesion revascularization.
RESULTS: The registry included 68 of the 1908 (3.6%) patients that underwent percutaneous coronary intervention. Procedural success was as high as 94% and more than 90% of cases were treated without any complication. The most common complication during PCI with RA was vessel dissection (8.8%) and no procedural death occurred. None of the clinical nor procedural characteristics were associated with burr entrapment or vascular access hematoma. We identified as independent predictor of treated vessel dissection the female sex (OR 16.9, 95% CI 1.55-183.77, P<0.05). Logistic regression revealed age (OR 1.17, 95% CI: 1.02-1.33, P<0.02) as the only independent predictor of MACE. We therefore calculated the ROC curve on age in predicting MACE, that showed a C-statistics of 0.75 (95% CI 0.628 to 0.852, P=0.02), with 80 years old as the best threshold in defining high risk population.
CONCLUSIONS: RA is a feasible and safe procedure. Females and elderly patients must be carefully selected in order to balance the risk/benefit ratio in these high-risk populations.


KEY WORDS: Percutaneous coronary intervention; Atherectomy, coronary; Coronary artery disease

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