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Minerva Cardioangiologica 2019 April;67(2):87-93

DOI: 10.23736/S0026-4725.19.04879-5


lingua: Inglese

Novel ultra-long (48 mm) everolimus-eluting stent for diffusely coronary vessels disease

Lorenzo GENUARDI, Francesco BURZOTTA , Giulio RUSSO, Osama SHOEIB, Diana VERDIROSI, Cristina AURIGEMMA, Giampaolo NICCOLI, Italo PORTO, Antonio M. LEONE, Carlo TRANI

Institute of Cardiology, A. Gemelli IRCCS University Policlinic Foundation, Sacred Heart Catholic University, Rome, Italy

BACKGROUND: Long drug-eluting stents may limit the need of stent overlaps in patients with diffusely diseased coronary arteries. We evaluated the clinical results of percutaneous-coronary-intervention (PCI) using a novel ultra-long (48 mm) everolimus-eluting stent (EES) in a real-word population.
METHODS: Patients who underwent PCI with 48 mm EES between June 2015 and April 2017 in our Center were enrolled. The only exclusion criteria was cardiogenic shock established before PCI. Target vessels were divided in “very long lesion” (>38 mm) and “multiple focal disease” (multiple stenoses separated by healthy coronary segments >10 mm). Clinical follow-up was obtained to evaluate the occurrence of device-oriented composite endpoint (DOCE) (primary end-point).
RESULTS: A total of 216 patients were identified (70.6±11 years, 48.1% acute coronary syndrome) who were treated on 230 vessels. The target vessel appearance was “very long lesion” in 44.8% of cases and “multiple focal disease” in 55.2%. A single 48-mm EES was implanted in 129 (56.1%), while additional overlapping stents were needed in 101 cases (43.9%). Total stent length was 64.9±24.0 mm. The median follow-up time was of 474 (411-614) days, DOCE occurred in 7% of patients. No stent thrombosis was noticed. At multivariate analysis, diabetes was associated with DOCE increase (P=0.02), while “multiple focal disease” predicted lower DOCE (P=0.02).
CONCLUSIONS: The present real-world experience shows promising clinical results with the use of ultra-long stents in order to limit the need of stents overlaps in patients with diffuse coronary disease undergoing PCI.

KEY WORDS: Coronary artery disease; Percutaneous coronary intervention; Drug-eluting stents

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