Home > Riviste > Minerva Cardioangiologica > Fascicoli precedenti > Minerva Cardioangiologica 2019 February;67(1) > Minerva Cardioangiologica 2019 February;67(1):79-83

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE   Freefree

Minerva Cardioangiologica 2019 February;67(1):79-83

DOI: 10.23736/S0026-4725.18.04795-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Interaction study between antiplatelet agents, anticoagulants, diabetic therapy and a novel delivery form of quercetin

Antonella RIVA 1, Ambra CORTI 2, Gianni BELCARO 3, Maria R. CESARONE 3, Mark DUGALL 3, Giulia VINCIGUERRA 4, Beatrice FERAGALLI 3, Mariachiara ZUCCARINI 3, Roberto EGGENHOFFNER 5, Luca GIACOMELLI 2, 5

1 Indena S.p.A, Milan, Italy; 2 Polistudium SRL, Milan, Italy; 3 IRVINE3 Vascular Lab, Department of Medical, Oral and Biotechnological Sciences, Chieti-Pescara University, Chieti, Italy; 4 Faculty of Motor Sciences, University of L’Aquila, L’Aquila, Italy; 5 Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy



BACKGROUND: In this pilot non-interference clinical study we evaluated possible interactions between Quercetin Phytosome® (Quercefit™), an innovative delivery form of quercetin, and antiplatelet agents, anticoagulants, and anti-diabetic therapy in otherwise healthy subjects.
METHODS: Interaction with antiplatelet therapy was assessed through the bleeding time (BT) test in 30 patients treated with acetylsalicylic acid, ticlopidine or clopidogrel before and after 10 days of supplementation with Quercetin Phytosome®. Interaction with anticoagulants was evaluated by measuring the International Normalized Ratio (INR) in 20 patients using warfarin or dabigatran before and after 20 days of supplementation with Quercetin Phytosome®. Lastly, glycaemia and glycated hemoglobin were measured in 12 diabetic patients treated with metformin and restricted diet before and after 20 days of supplementation with Quercetin Phytosome®.
RESULTS: After 10 days of supplementation no significant difference was observed in mean BT in patients treated with acetylsalicylic acid, ticlopidine or clopidogrel at standard dosages. Similarly, after 20 days of supplementation, the INR level among patients assuming warfarin or dabigatran was not statistically different from baseline. Lastly, no statistically significant difference in mean levels of glycaemia and glycated hemoglobin was reported before and after 20 days of complementary administration of Quercetin Phytosome® in diabetic patients treated with metformin and restricted diet.
CONCLUSIONS: Quercetin Phytosome® does not alter the antiplatelet activity of the most common antiplatelet agents, has no impact on the INR values in stable patients treated with warfarin or dabigatran, and does not influence the metabolic control of diabetic patient treated with metformin.


KEY WORDS: Quercetin - Anticoagulants - Cardiovascular diseases

inizio pagina