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REVIEWS  THE PREDICTIVE VALUE OF PLASMA BIOMARKERS IN DISCHARGED HEART FAILURE PATIENTS 

Minerva Cardioangiologica 2016 April;64(2):157-64

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

The predictive value of plasma biomarkers in discharged heart failure patients: role of plasma NT-proBNP

Laura LETO 1, Marzia TESTA 2, Mauro FEOLA 1

1 Cardiovascular Rehabilitation-Heart Failure Unit, Ospedale SS Trinità, Fossano, Cuneo, Italy; 2 School of Geriatry, Università degli Studi di Torino, Turin, Italy


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BACKGROUND: Natriuretic peptides (NPs) have demonstrated their value to support clinical diagnosis of heart failure (HF); furthermore they are also studied for their prognostic role using them to guide appropriate management strategies. The present review gathers available evidence on prognostic role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients hospitalized for acute decompensated heart failure (ADHF).
METHODS: We searched Medline for English-language studies with the sequent key-words: “acute heart failure/acute decompensated heart failure”, “NT-proBNP/N-terminal pro-B type natriuretic peptide” and “prognosis/mortality/readmission”.
RESULTS: Almost 30 studies were included. NT-proBNP plasma levels at admission are strongly associated with all-cause short-term mortality (2-3 months), mid-term (6-11 months) or long- term mortality (more than one year) of follow-up. Regarding the prognostic power on cardiac death fewer data are available with uncertain results. NT-proBNP at discharge demonstrated its prognostic role for all-cause mortality at mid and long-term follow-up. The relation between NT-proBNP at discharge and cardiovascular mortality or composite end-point is under investigation. A decrease in NT-proBNP values during hospitalization provided prognostic prospects mainly for cardiovascular mortality and HF readmission. A 30% variation in NT-proBNP levels during in-hospital stay seemed to be an optimal cut-off for prognostic role.
CONCLUSIONS: NT-proBNP plasma levels proved to have a strong correlation with all-cause mortality, cardiovascular mortality, morbidity and composite outcomes in patients discharged after an ADHF. A better definition of the correct time of serial measurements and the cut-off values might be the challenge for the future investigations.

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