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Minerva Biotecnologica 2018 December;30(4):108-12

DOI: 10.23736/S1120-4826.18.02427-8


lingua: Inglese

Zinc as a modulator of membrane stability parameters during prostate cancer

Haiping WANG 1, Ruiyu HAN 2

1 Department of Surgery, Shaanxi Traditional Chinese Medicine Hospital, Xi’an, Shaanxi Province, China; 2 Key Laboratory of Family Planning and Health Birth, National Health and Family Planning Commission, Hebei Research Institute for Family Planning, Xinhua District, Shijiazhuang, Hebei Province, China

BACKGROUND: The present study explored the potential of zinc on membrane fluidity changes in 3,2’-dimethyl4amino-biphenyl (DMAB)-induced prostate cancer.
METHODS: Rats were segregated into four groups viz., normal control, DMAB treated, zinc treated, DAMB+zinc treated. Brush border membranes (BBM) were isolated from the rats and using the membrane extrinsic fluorophore pyrene, we assessed the viscosities as well as fluidity parameters.
RESULTS: DMAB treatment resulted in a significant rise in lipid peroxidation (LPO). Reduced glutathione levels (GSH) and the activities of glutathione reductase (GR), glutathione transferase (GST), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were found to be significantly decreased following DMAB treatment. On the other hand, zinc treatment to DMAB treated rats resulted in a significant decrease in the levels of LPO but caused a significant rise in the levels of GSH as well in the activities of GR, GST, SOD, CAT and GPx. The results further, demonstrated a marked decrease in membrane microviscosity following DMAB treatment. On the other hand, a significant increase was observed in the excimer/monomer ratio and fluidity parameter of DMAB treated rats when compared to normal control rats. However, the alterations in membrane microviscosity and the fluidity parameters were significantly restored after zinc treatment.
CONCLUSIONS: The study, therefore, concludes that zinc proved quite useful in modulation of membrane stability parameters following DMAB induced prostate cancer.

KEY WORDS: Prostatic neoplasms - Membranes - Zinc

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