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Minerva Biotecnologica 2017 September;29(3):109-13

DOI: 10.23736/S1120-4826.17.02220-0

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Non-organ-specific autoimmunity in patients suffering from gastric ulcer with and without Helicobacter pylori infection

Marco ASTEGIANO 1, Giovanni A. TOUSCOZ 1, Gian P. CAVIGLIA 2, Davide G. RIBALDONE 1, Claudio DE ANGELIS 1, Sergio PEYRE 3, Antonina SMEDILE 1, 2, Giorgio M. SARACCO 1, 2, Rinaldo PELLICANO 1

1 Gastroenterology Unit, Molinette Hospital, Turin, Italy; 2 Department of Medical Sciences, University of Turin, Turin, Italy; 3 Gastroenterology Unit, Cuorgné Hospital, Cuorgné, Turin, Italy


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BACKGROUND: To evaluate the prevalence of non-organ specific autoantibodies (NOSAs) in patients with gastric ulcer (GU) associated or not with Helicobacter pylori (H. pylori) infection.
METHODS: We compared 43 patients (26M/17F, median age 63 years) suffering from GU and H. pylori infection to 39 subjects (19M/20F, median age 69 years) affected by GU caused by the assumption of non-steroidal anti-inflammatory drugs (NSAIDs). H. pylori infection was diagnosed by histology and 13C-urea breath test. Autoimmunity was assessed by the presence of NOSAs in serum. All patients with H. pylori infection were treated with one or more antibiotic regimens to eradicate the bacterium.
RESULTS: Antinuclear (ANA), anti-smooth muscle (ASMA) and anti-liver/kidney microsomal-1 (LKM-1) antibodies were present respectively in 5 (11.6%), 1 (2.3%) and none out of 43 patients with GU and H. pylori infection. Considering the 39 patients with NSAIDs-related GU, ANA was present in 5 (12.8%), ASMA in 3 (7.7%) and anti-LKM-1 in none. The difference was not significant. All but one H. pylori infected subjects (97.7%) eradicated the bacterium with a multistep strategy; in none of them significant changes in terms of prevalence or titer of NOSAs, after 6 months of follow-up were observed.
CONCLUSIONS: In patients with GU, H. pylori infection is not associated with an increased prevalence of NOSAs and the cure of the bacterium does not influence the NOSAs profile.


KEY WORDS: Autoantibodies - Autoimmunity - Helicobacter pylori - Stomach ulcer - Peptic ulcer

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