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  APPLICATIONS OF PEPTIDES NUCLEIC ACIDS (PNA) IN MOLECULAR MEDICINE AND BIOTECHNOLOGY 

Minerva Biotecnologica 1999 September;11(3):211-9

Copyright © 1999 EDIZIONI MINERVA MEDICA

lingua: Inglese

New approaches for the delivery of oligonucleotides (ODNs)

Ricci M. 1, Esposito E. 2, Nastruzzi C. 1

1 Istituto di Chimica e Tecnologia del Farmaco, Università degli Studi, Perugia, Italy; 2 Dipartimento di Scienze Farmaceutiche, Università degli Studi, Ferrara, Italy


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The aim of ­this ­paper is to ­review the ­most ­recent ­approaches for the trans­port and ­delivery of oli­go­nu­cleo­tides (­ODNs) in dif­ferent bio­log­ical ­systems ­with spe­cial ­regard to (a) alter­na­tive admin­is­tra­tion ­routes (­with ­respect to the intra­ve­nous admin­is­tra­tion) and (b) strat­e­gies for ODN ­delivery ­based on poly­meric par­ti­cles. The key fac­tors ­affecting mac­ro­mol­e­cule absorp­tion ­have ­been of ­interest for ­many ­years in the ­field of ­drug ­delivery and tar­geting and in the pro­duc­tion of mac­ro­mo­lec­ular pro-­drugs and spe­cial­ized ­delivery ­systems. In ­this ­respect, it ­should be under­lined ­that ­there are ­many fac­tors ­that influ­ence the ­extent and dura­tion of bio­log­ical ­activity fol­lowing the admin­is­tra­tion of a ­gene med­i­cine ­such as ­ODNs. ­Delivery is a fun­da­mental com­po­nent of ­activity, ­which we ­review ­here but the ­design and opti­mi­za­tion of the ­nucleic ­acid mole­cule ­will ­also be a ­major ­part of the devel­op­ment of a suc­cessful ­gene med­i­cine.

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