REVIEW   

Minerva Biotecnologica 2018 June;30(2):63-8

DOI: 10.23736/S1120-4826.18.02385-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Current perspectives of nuclear magnetic resonance metabolomics in melanoma

Zhenhe LIU, Guanzhong ZHAI, Litao LIU, Jinguo ZHANG ✉

Department of Radiology, Dezhou People’s Hospital of Shandong Province, Dezhou, China

The metabolomics has now become an established part of biomedical research and NMR metabolomics is a highly reproducible, low cost method of conducting studies of the metabolism of biological systems. The present review article is focused on the current knowledge nuclear magnetic resonance (NMR) metabolomics in melanoma. ROCK is a novel therapeutic target of melanoma as it has recently been shown that small molecule inhibitors of ROCK could reduce melanoma growth and the number of metastases in vivo. -Omics level studies of biological systems are quickly becoming an integral and routine part of biological research. NMR metabolomics is a relatively cheap and highly reproducible means of identifying 30-100 different metabolites in a biological system. Recent repots have suggested Rho Kinase (ROCK) metabolism as a crucial parameter in the cases of melanoma. So, the present review article would discuss the potential of NMR metabolomics with special reference to ROCK metabolism in melanoma.

KEY WORDS: Nuclear magnetic resonance, biomolecular - Metabolomics - Melanoma