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Minerva Biotecnologica 2014 December;26(4):287-93


lingua: Inglese

Phytochemical screening and antibacterial activity of Prosopis farcta different parts extracts against methicillin-resistant Staphylococcus aureus (MRSA)

Sharifi-Rad J. 1, 2, Hoseini-Alfatemi S. M. 3, Sharifi-Rad M. 4, Miri A. 1, 2, Sharifi-Rad M. 5

1 Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran; 2 Department of Pharmacognosy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran; 3 Pediatric Infections Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4 Department of Range and Watershed Management, Faculty of Natural Resources, University of Zabol, Iran; 5 Zabol University of Medical Sciences, Zabol, Iran


The present study investigated the phytochemical screening and antibacterial potentiality of different parts (roots, leaf, pods and seeds) of the Prosopis farcta extracts against Methicillin-resistant Staphylococcus aureus (MRSA). Phytochemical screening of the P. farcta methanolic extract was carried out for estimation of saponins, glycosides, alkaloids, tannins and flavonoids by using standard phytochemical screening methods. The antibacterial activity was determined by both the disc diffusion method and the microbroth dilution method. Antibacterial screening of P. farcta extracts showed that inhibited zones for roots, leaf, pods and seeds extract were 5±0.1, 6±0.4, 8±06 and 12±0.1 mm, respectively. MIC for roots, leaf, pods and seeds extract were 45±0.4, 35.5±0.8, 15±0.1 and 5±0.4 µg/mL, respectively. MBC for roots, leaf, pods and seeds extract were 100±0.4, 75±0.3, 25±0.5, and 5±0.2 µg/mL, respectively. In this study, MIC range for Vancomycin was between 0.4-4 μg/mL for all strains isolated from various clinical samples. All P. farcta extracts exhibited different degrees of antibacterial activity on MRSA; this difference is mainly due to the presence of different components in these parts. The seeds extract showed more effect than other parts of the plant on the bacteria tested. This effect may be related to high concentrations of alkaloids, tannins or glycosides in this part. These components are known to high antibacterial activity. P. farcta extracts possess potent antibacterial against MRSA, and may be used as an antibacterial to treat diseases.

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