ORIGINAL ARTICLES  BIOENCAPSULATION IN BIOTECHNOLOGY 

Minerva Biotecnologica 2007 June;19(2):71-4

Copyright © 2007 EDIZIONI MINERVA MEDICA

lingua: Inglese

Antibody-antigen interactions in dielectrophoresis buffers for cell manipulation on dielectrophoresis-based Lab-on-a-chip devices

Borgatti M. ¹, Rizzo R. ², Mancini I. ¹, Fabbri E. ¹, Baricordi O. ², Gambari R. ^{1, 3}

¹ Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassemia Biotechnology Center, University of Ferrara, Ferrara, Italy 2 Section of Human Genetic, Department of Experimental and Diagnostic Medicine University of Ferrara, Ferrara, Italy 3 ER-GenTech, Department of Biochemistry and Molecular Biology University of Ferrara, Ferrara, Italy

In this review we present data supporting the feasibility to perform experiments based on dielectrophoresis (DEP) and on molecular interactions between monoclonal antibodies and membrane proteins. This allows propose DEP-based Lab-on-a-chip platforms for several biotechnological applications depending on the interactions between monoclonal antibodies and target cells, including immunophenotype characterization, isolation of rare cells, drug targeting.