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ORIGINAL ARTICLE   

Minerva Biotecnologica 2020 December;32(4):165-74

DOI: 10.23736/S1120-4826.20.02687-7

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Identification and analysis of key regulatory genes associated with pre-eclampsia: a systems biology approach

Lin LIN, Xiaoqian LIN, Zhaodong LIU, Huale ZHANG, Qing HAN, Rongxin CHEN, Lichun CHEN, Jianying YAN

Department of Obstetrics, Fujian Provincial Maternity and Children Hospital, the Affiliated Hospital of Fujian Medical University, Fuzhou, China



BACKGROUND: Pre-eclampsia is a disorder marked by hypertension during pregnancy that is a leading cause of maternal and infant morbidity, mortality, and premature births worldwide. Pre-eclampsia is thought to result from a poor placental perfusion of unclear causes. Gene expression profiles of placenta-associated genes have been shown to be altered in patients with pre-eclampsia, but the actual regulators remain unknown. We aimed to identify and analyze key regulatory genes associated with pre-eclampsia.
METHODS: In this paper, we analyzed the gene expression profiles of placentas of women with first-trimester pre-eclampsia to identify key regulators; in addition, we performed protein-protein interaction, gene ontology (GO) enrichment, and pathway analyses.
RESULTS: After applying log fold-change statistics, we found 231 differentially expressed genes (DEGs) between normal and pre-eclampsia placentas. We confirmed through downstream analyses that these genes are associated with CYP-mediated steroid metabolism and hydroxylation in pregnancy, with glucuronidation and hyperbilirubinemia, and with other biological pathways.
CONCLUSIONS: The identified DEGs associated with pre-eclampsia may be targeted in studies to clarify the pathogenesis of this condition.


KEY WORDS: Pre-eclampsia; Microarray analysis; Genome-wide association study

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