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Original Paper   

Minerva Anestesiologica 2022 Jul 14

DOI: 10.23736/S0375-9393.22.16728-3


lingua: Inglese

Long-term effects of Coronavirus 2 infection after intensive care: a prospective study

Vincenzo DAMICO 1 , Liana MURANO 2, Viola MARGOSIO 1, Niccolò TOGNONI 1, Alberto DAL MOLIN 3, Erika BASSI 3, Erica BUSCA 3, Francesco CRIMELLA 1

1 Azienda Socio Sanitaria Territoriale of Lecco, Lecco, Italy; 2 Sanitary Assistance Residency, Madonna della Neve Onlus, Premana, Lecco, Italy; 3 Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy


BACKGROUND: While the multi-organ manifestations of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection are now well-documented, the potential long-term implications of these manifestations remain to be uncovered. The aim was to study the level and predictors of post-traumatic stress, anxiety and depression symptoms, quality of life and functional disability in COVID-19 survivors during the first year post intensive care unit (ICU) discharge.
METHODS: A prospective longitudinal study, reported following the STROBE guidance, was conducted in adult patients with SARS-CoV-2 infection admitted to an Italian ICU from March 2020 to March 2021 who were followed until March 2022.
RESULTS: A total of 207 patients were included in the study, of which 145 (70.1%) were male. One hundred and six (51.2%) patients between six and 12 months after ICU discharge reported at least one physical or cognitive impairment. The concurrent prevalence of anxiety, depression and PTSD is present in 25/106 patients (23.6% of cases) at six months and increases in 29/106 patients (27.3% of cases) at 12 months. However, the prevalence of anxiety, depression and PTSD was observed in 86 patients (41.5%) at six months and it gets smaller in 78 patients (37.7%) at 12 months (p= .049). The EqVAS score (58.8 vs 72.3, p= .017) and the Barthel Index (61.5 vs 74.8, p< .001) increased significantly between six and 12 months after ICU.
CONCLUSIONs: Our results show that functional and cognitive recovery improves between six and 12 months after ICU discharge with a high perception of the patients' quality of life.

KEY WORDS: Coronavirus; Intensive Care Unit; Post-COVID-19 syndrome; Risk factors

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