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MINERVA ANESTESIOLOGICA

Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
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Minerva Anestesiologica 2018 Mar 07

DOI: 10.23736/S0375-9393.18.12312-1

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Comparison of the effects of low doses of dexmedetomidine and remifentanil on the maternal haemodynamic changes during caesarean delivery in patients with severe preeclampsia: a randomised trial

Mohamed R. EL-TAHAN 1 , Samah EL KENANY 2, Ehsan M. ABDELATY 3, Eiad A. RAMZY 2

1 Anaesthesiology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Al Khubar, Saudi Arabia; 2 Department of Anaesthesia, Surgical Intensive Care and Pain Medicine, College of Medicine, Mansoura University, Mansoura City, Egypt; 3 Department of Clinical Pathology, College of Medicine, Mansoura University, Mansoura City, Egypt;


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BACKGROUND: Preoperative remifentanil administration blunts haemodynamic responses to tracheal intubation in parturients with severe preeclampsia. We hypothesised that the preoperative administration of low doses of remifentanil or dexmedetomidine would lead to comparable maternal neurohormonal responses and neonatal outcomes in patients with severe preeclampsia.
METHODS: Parturients diagnosed with severe preeclampsia undergoing caesarean delivery were randomly allocated to receive remifentanil (0.1 μg/kg/min) or dexmedetomidine (0.4 μg/kg/h) at five min and 20 min before induction, respectively. Changes in maternal mean arterial blood pressure (MAP), clinical recovery, cortisol level, and neonatal outcome, were recorded.
RESULTS: Patients who received remifentanil had higher response in MAP at the induction (94 9.8 vs. 104 4.5; p<0.001) and emergence from anaesthesia (94 6.3 vs. 98 5.1; p<0.001), but shorter times to extubation (5.1 1.6 vs. 13.5 2.8 min; p<0.001). Five (27.8%) patients in the remifentanil group received ephedrine versus none in the dexmedetomidine group (p=0.023). The maternal plasma cortisol levels, the neonatal Neurologic and Adaptative Capacity Scores and acid-base satuses were similar in the two groups. Newborns in the remifentanil group presented lower Apgar scores at 1 min (5.11 0.8 vs. 5.68 0.8; p=0.034) and a higher incidence of respiratory depression (72.2% vs. 36.8% p=0.048).
CONCLUSIONS: Compared with dexmedetomidine (0.4 μg/kg/h), the preoperative administration of remifentanil (0.1μg/kg/min) produced a significantly higher effect on maternal haemodynamic responses to caesarean delivery in patients with severe preeclampsia, however maternal hypotension and neonatal respiratory depression were more common with the use of remifentanil.


KEY WORDS: Caesarean delivery - Preeclampsia - Remifentanil - Dexmedetomidine - Cardiovascular response

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Publication History

Article first published online: March 7, 2018
Manuscript accepted: March 6, 2018
Manuscript revised: February 26, 2018
Manuscript received: July 21, 2017

Per citare questo articolo

El-Tahan MR, El Kenany S, Abdelaty EM, Ramzy EA. Comparison of the effects of low doses of dexmedetomidine and remifentanil on the maternal haemodynamic changes during caesarean delivery in patients with severe preeclampsia: a randomised trial. Minerva Anestesiol 2018 Mar 07. DOI: 10.23736/S0375-9393.18.12312-1

Corresponding author e-mail

mohamedrefaateltahan@yahoo.com