Home > Riviste > Minerva Anestesiologica > Fascicoli precedenti > Articles online first > Minerva Anestesiologica 2018 Jan 16



Publication history
Per citare questo articolo


Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,623



Minerva Anestesiologica 2018 Jan 16

DOI: 10.23736/S0375-9393.18.12070-0


lingua: Inglese

Patient controlled epidural analgesia with and without basal infusion using ropivacaine 0.15% and fentanyl 2γ/mL for labour analgesia: a prospective comparative randomised trial

Paraskevi K. MATSOTA 1 , Kalliopi H. DRACHTIDI 1, Chrysanthi Z. BATISTAKI 1, Agathi V. KARAKOSTA 2, Ioanna C. KOUKOPOULOU 1, Eugenia I. KOURSOUMI 1, Georgia G. KOSTOPANAGIOTOU 1

1 2nd Department of Anaesthesiology, School of Medicine, National and Kapodistrian University of Athens, “Attikon” University Hospital, Athens, Greece; 2 Thriassio General Hospital, NHS, Magoula, Athens, Greece


BACKGROUND: Patient-Controlled Epidural Analgesia (PCEA) is a common practice for labour pain relief. This study aimed to compare two different settings of a PCEA device using the same solution to obtain labour analgesia.
METHODS: Fifty two parturients were randomly allocated to receive ropivacaine 0.15% and fentanyl 2γ/mL via a PCEA device either as a background infusion of 5mL/h plus 5mL demand bolus doses with 10 min lockout (group B/D, n=26) or as only demand bolus doses of 5mL with 10 min lockout (group D, n=26). The primary outcome was the total volume of local anaesthetic administrated during labour; secondary outcomes included the analgesic efficacy and the effects on maternal and neonatal outcomes.
RESULTS: No statistical difference was observed between the groups concerning demographic characteristics, duration of first and second stages of labour, administration of oxytocin and ephedrine, rescue doses, instrumental delivery, Bromage scale, maternal side effects and satisfaction, neonatal Apgar scores and pH. The total volume of local anaesthetic was greater in group B/D compared to group D (p=0.015). A statistically significant difference was detected in VAS scores only at the end of the second stage (p=0.036) and at 60 min from the test dose administration (p=0.022) and with group D exhibited higher pain scores than group B/D. The incidence of breakthrough pain (VAS>4) was higher in group D compared with Group B/D (p=0.035).
CONCLUSIONS: The addition of background infusion plus PCEA demand bolus doses increased local anaesthetic consumption and reduced breakthrough pain without affecting maternal satisfaction and neonatal outcomes.

KEY WORDS: PCEA - Labour analgesia - Background infusion - Ropivacaine - Fentanyl

inizio pagina

Publication History

Article first published online: January 16, 2018
Manuscript accepted: January 10, 2018
Manuscript revised: November 8, 2017
Manuscript received: March 14, 2017

Per citare questo articolo

Matsota PK, Batistaki CZ, Karakosta AV, Koukopoulou IC, Koursoumi EI, Kostopanagiotou GG. Patient controlled epidural analgesia with and without basal infusion using ropivacaine 0.15% and fentanyl 2γ/mL for labour analgesia: a prospective comparative randomised trial. Minerva Anestesiol 2018 Jan 16. DOI: 10.23736/S0375-9393.18.12070-0

Corresponding author e-mail