Home > Riviste > Minerva Anestesiologica > Fascicoli precedenti > Articles online first > Minerva Anestesiologica 2017 Nov 06

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

MINERVA ANESTESIOLOGICA

Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 2,623


eTOC

 

Minerva Anestesiologica 2017 Nov 06

DOI: 10.23736/S0375-9393.17.12194-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Gabapentin given before laparoscopic sleeve gastrectomy reduces postoperative oxycodone consumption in obese patients. A randomized double-blind placebo-controlled trial

Anna RUPNIEWSKA-LADYKO , Małgorzata MALEC-MILEWSKA, Ewa KRASZEWSKA, Michal PIROZYNSKI

Department of Anesthesiology and Intensive Care, Centre of Postgraduate Medical Education, Warsaw, Poland


PDF  


BACKGROUND: Post-operative pain can be prevented. Gabapentin may be effective in this role. Our primary objective was to test the hypothesis that a prophylactic administration of gabapentin in obese patients before surgery has an opioid-sparing effect and reduces postoperative oxycodone consumption more efficiently than placebo.
METHODS: The study enrolled 113 patients undergoing laparoscopic sleeve-gastrectomy under general anesthesia. The patients were randomly allocated to the control or gabapentin group and received a single oral dose of gabapentin 1200 mg or a matching placebo 1 h before surgery.
RESULTS: The mean (SD) time from the end of anesthesia to the commencement of analgesic therapy was 74,3 min (37,8) in the placebo group and 110,4 min (65,4) with gabapentin (mean difference: -36, 95% CI [12 to 40], P=0,0004). The mean 12 h oxycodone consumption was 31,5 mg (10) with placebo and 26,3 mg (10) with gabapentin (mean difference: -5,2 mg, 95% CI [-9,08 to -1,35] P=0.0085). The mean (SD) NRS pain intensity at 12 h was 2 (0,9) in the placebo group, and 1,5 (0,9) with gabapentin (mean difference: -0,5, 95% CI [0,15 to 0,81], P=0,003).
CONCLUSIONS: The demand for oxycodone was delayed in the gabapentin group; also, the total 12 h dose requirement of oxycodone was lower in the gabapentin group.


KEY WORDS: Gabapentin - Opioid-sparing effect - obesity - PCA clinical advantages - Post-operative analgesic effect - Bariatric surgery

inizio pagina

Publication History

Article first published online: November 06, 2017
Manuscript accepted: October 30, 2017
Manuscript revised: September 27, 2017
Manuscript received: May 22, 2017

Per citare questo articolo

Rupniewska-Ladyko A, Malec-Milewska M, Kraszewska E, Pirozynski M. Gabapentin given before laparoscopic sleeve gastrectomy reduces postoperative oxycodone consumption in obese patients. Minerva Anestesiol 2017 Nov 06. DOI: 10.23736/S0375-9393.17.12194-2

Corresponding author e-mail

aavr@interia.pl