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Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva

Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Anestesiologica 2017 Sep 11

DOI: 10.23736/S0375-9393.17.12130-9


lingua: Inglese

How to optimize the lung donor

Gabriele SALES 1, Andrea COSTAMAGNA 1, Vito FANELLI 1, Massimo BOFFINI 1, Francesco PUGLIESE 2, Luciana MASCIA 3, Luca BRAZZI 1

1 Department of Surgical Sciences, University of Turin, Turin, Italy; 2 Department of General and Specialist Surgery “Paride Stefanini”, University of Rome “La Sapienza”, Rome, Italy; 3 Department of Biotechnological and Medical and Surgical Sciences ”, University of Rome “La Sapienza”, Rome, Italy


In the last two decades, lung transplantation emerged as the standard of care for patients with advanced and terminal lung disease. Despite the increment in lung transplantation rates, in 2016 the overall mortality while on waiting list in Italy reached the 10%, whereas only the 39% of the wait-list patients were successfully transplanted. A number of approaches, including protective ventilatory strategy, accurate management of fluid balance, administration of a hormonal resuscitation therapy have been reported to improve lung donor performance before organ retrieval. These approaches, in conjunction with the use of ex-vivo lung perfusion technique contributed to expand the lung donor pool, without affecting the harvest of other organs and the outcomes of lung recipients. But the efficacy of issues related to the ex-vivo lung perfusion technique, such as the optimal ventilation strategy, the ischemia-reperfusion induced lung injury management, the prophylaxis of germs transmission from donor to recipient and the application of targeted pharmacologic therapies to treat specific donor lung injuries are still to be explored. The main objective of the present review is to summarize the ‘state of art’ strategies to optimize the donor lungs and to present the actual role of ex-vivo lung perfusion in the process of lung transplant. Moreover, different approaches about the technique reported in literature and several issues that are under investigation to treat specific donor lung injury will be discussed.

KEY WORDS: Lung transplantation - Organ preservation - Lung injury - Donor selection

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Publication History

Article first published online: September 11, 2017
Manuscript accepted: September 1, 2017
Manuscript revised: July 17, 2017
Manuscript received: April 10, 2017

Per citare questo articolo

Sales G, Costamagna A, Fanelli V, Boffini M, Pugliese F, Mascia L, et al. How to optimize the lung donor. Minerva Anestesiol 2017 Sep 11. DOI: 10.23736/S0375-9393.17.12130-9

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