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MINERVA ANESTESIOLOGICA

Rivista di Anestesia, Rianimazione, Terapia Antalgica e Terapia Intensiva


Official Journal of the Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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Minerva Anestesiologica 2017 Jul 20

DOI: 10.23736/S0375-9393.17.12016-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Machine perfusion in liver transplantation - an essential treatment or just an expensive toy?

Andrea A. SCHLEGEL 1, 2, 3, 4, Marit KALISVAART 1, Paolo MUIESAN 1, 3

1 The Liver Unit, Queen Elizabeth University Hospital Birmingham, Birmingham, United Kingdom; 2 NIHR Liver Biomedical Research Unit, University Hospitals Birmingham, Birmingham, UK; 3 Department of Liver Surgery, Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UKM; 4 Department of Surgery & Transplantation, University Hospital Zurich, Zurich, Switzerland


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This review focuses on recent developments in preservation techniques in liver transplantation. First, we discuss mechanisms of organ injury when using high-risk organs, including DCD and steatotic grafts and we summarize pathways of ischemia reperfusion injury together with their link to the immune response. Second, we report on improvement strategies of marginal liver grafts by different machine perfusion concepts and summarize perfusion approaches with recent clinical implementation.


KEY WORDS: Machine perfusion - Extended criteria grafts - Hypothermic oxygenated perfusion - Viability testing - Biomarker

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Publication History

Article first published online: July 20, 2017
Manuscript accepted: July 19, 2017
Manuscript revised: June 20, 2017
Manuscript received: February 22, 2017

Per citare questo articolo

Schlegel AA, Kalisvaart M, Muiesan P. Machine perfusion in liver transplantation - an essential treatment or just an expensive toy?. Minerva Anestesiol 2017 Jul 20. DOI: 10.23736/S0375-9393.17.12016-X

Corresponding author e-mail

Paolo.Muiesan@uhb.nhs.uk