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Minerva Anestesiologica 2019 January;85(1):21-7

DOI: 10.23736/S0375-9393.18.12703-9

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Oral flurbiprofen spray for postoperative sore throat and hoarseness: a prospective, randomized, double-blind, placebo-controlled study

Togay MUDERRIS 1 , Gunay TEZCAN 2, Mecit SANCAK 3, Fatih GUL 3, Gokcer UGUR 4

1 Department of Otorhinolaryngology, Head and Neck Surgery, Bozyaka Education and Research Hospital, İzmir, Turkey; 2 Department of Anesthesiology, Faculty of Medicine, Okan University, Istanbul, Turkey; 3 Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk Education and Research Hospital, Ankara, Turkey; 4 Department of Anesthesiology, Ataturk Education and Research Hospital, Ankara, Turkey



BACKGROUND: Sore throat and hoarseness are common complications after surgery. Flurbiprofen spray has been successfully used for treatment of oral inflammations, but its effects on postoperative sore throat and hoarseness are unknown. We conducted this study to evaluate the effectiveness of flurbiprofen spray on postoperative sore throat and hoarseness, by comparing it with benzydamine hydrochloride spray and placebo.
METHODS: One hundred fifty patients who were scheduled to undergo elective ear surgery were enrolled. Patients were randomized to three groups of 50 patients each; flurbiprofen oral spray, benzydamine hydrochloride oral spray and placebo spray groups. Patients received sprays just before intubation, and the incidence and severity of postoperative sore throat and hoarseness were evaluated by a blinded investigator at 0, 1, 6 and 24-hour post extubation. Patients were also questioned for possible side effects at all time points.
RESULTS: The sore throat severity scores were significantly lower in treatment groups when compared to placebo group at all time points (P=0.003/108). Similarly, the incidence of sore throat was significantly lower in both of the treatment groups (P=0.007/104). The incidence of hoarseness and hoarseness scores were significantly lower in treatment groups when compared to placebo group (P=0.006/105 and P=0.005/104, respectively). While none of the patients complained of any adverse effects in flurbiprofen group, only two patients in benzydamine hydrochloride group experienced numbness.
CONCLUSIONS: Both oral flurbiprofen and benzydamine hydrochloride sprays were found to be more effective than placebo in decreasing the incidence and severity of postoperative sore throat and hoarseness, with no adverse effects.


KEY WORDS: Postoperative period - Intubation - Hoarseness - Flurbiprofen - Benzydamine

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