Home > Riviste > Minerva Anestesiologica > Fascicoli precedenti > Minerva Anestesiologica 2018 September;84(9) > Minerva Anestesiologica 2018 September;84(9):1032-43

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE   Freefree

Minerva Anestesiologica 2018 September;84(9):1032-43

DOI: 10.23736/S0375-9393.18.12150-X

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

The effect of various doses of infusion solutions on the endothelial glycocalyx layer in laparoscopic cholecystectomy patients

Matija BELAVIĆ 1, Vlatka SOTOŠEK TOKMADŽIĆ 2, Elizabeta FIŠIĆ 3, Antonija BROZOVIĆ KRIJAN 1, Nedjeljko STRIKIĆ 4, 5, Mirjana LONČARIĆ KATUŠIN 1, Josip ŽUNIĆ 1, 5

1 Department of Anesthesiology, Resuscitation, and Intensive Medicine, Karlovac General Hospital, Karlovac, Croatia; 2 Department of Anesthesiology, Resuscitation, and Intensive Care, Faculty of Medicine, University of Rijeka, Rijeka, Croatia; 3 Clinical Institute of Laboratory Diagnostics, Rijeka Clinical Hospital Center, Rijeka, Croatia; 4 Department of Abdominal Surgery, Karlovac General Hospital, Karlovac, Croatia; 5 Karlovac University of Applied Sciences, Karlovac, Croatia



BACKGROUND: The endothelial glycocalyx is located on the luminal side of blood vessels and maintains vessel integrity. This study analysed how various dosages of infusion affected the secretion of atrial natriuretic peptide (ANP) and potential glycocalyx damage in patients undergoing laparoscopic cholecystectomy. We hypothesised that the liberal administration of Ringer’s solution during the operation can cause iatrogenic hypervolemia with releasing of ANP and glycocalyx damage.
METHODS: The study included 90 patients with American Society of Anesthesiologists’ (ASA) class I and II, in good cardiopulmonary health, who were assigned to one of three groups: Restrictive group, which received 1 mL/kg/hr intraoperatively and six hours postoperatively; Low liberal group, which received 5 mL/kg/hr of Ringer’s solution intraoperatively and six hours postoperatively and High liberal group, which received 15 mL/kg/hr intraoperatively and 10 mL/kg/hr six hours postoperatively. We measured patients’ concentrations of glycocalyx constituents, ANP, markers of kidney and liver function, C-reactive protein (CRP), and albumine at three time points. We also measured noinvasive hemodynamics, the correlation between ANP secretion and the concentration of glycocalyx components.
RESULTS: We found a significantly higher concentrations of hyaluronic acid and syndecan-1 and more ANP secretion in the High liberal group than in the other groups. We also observed a positive correlation between ANP secretion and glycocalyx constituent concentration. Markers of kidney and liver function were normal, suggesting preservation of splanchnic perfusion and global hemodynamics.
CONCLUSIONS: Measuring the endothelial glycocalyx constituents in circulating blood could be a marker of intraoperative volume overload during laparoscopic operations.


KEY WORDS: Atrial natriuretic factor - Cholecystectomy, laparoscopic - Fluid therapy - Glycocalyx - Heparan sulfate proteoglycans - Hyaluronic acid

inizio pagina