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Minerva Anestesiologica 2010 November;76(11):957-60

Copyright © 2010 EDIZIONI MINERVA MEDICA

lingua: Inglese

Successful treatment of multidrug-resistant Acinetobacter baumannii ventriculitis with intrathecal and intravenous colistin

De Pascale G. 1, Pompucci A. 2, Maviglia R. 3, Spanu T. 4, Bello G. 3, Mangiola A. 2, Scoppettuolo G. 1

1 Institute of Infectious Diseases, Catholic University School of Medicine, Rome, Italy; 2 Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy; 3 Department of Anesthesiology and Intensive Care, Catholic University School of Medicine, Rome, Italy; 4 Institute of Microbiology, Catholic University School of Medicine, Rome, Italy


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Acinetobacter baumannii (AB) nosocomial infections, especially those due to multi-drug resistant (MDR) strains, are increasingly detected. We report a case of a 42-year-old male patient affected by low-grade ependymoma who developed AB-MDR post-neurosurgical ventriculitis. Initially, because of in vitro susceptibility, we used a combination of intravenous colistin and tigecycline. This treatment resulted in the improvement of the patient’s initial condition. However, soon after, the infection relapsed; tigecycline was stopped and treatment with intrathecal colistin was initiated. Cure was achieved by continuing this treatment for approximately three weeks, without adverse effects.

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