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Minerva Anestesiologica 2010 February;76(2):115-9

Copyright © 2010 EDIZIONI MINERVA MEDICA

lingua: Inglese

The pharmacodynamic effects of rocuronium during general anesthesia in patients with type 2 diabetes mellitus

Alper I., Ulukaya S., Makay O., Balcioglu T.

Department of Anesthesiology and Reanimation, Ege University School of Medicine, Izmir, Turkey


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AIM. The aim of this prospective study was to investigate whether the neuromuscular response to rocuronium is affected by the presence of type 2 diabetes mellitus.
METHODS: Neuromuscular functions were measured after the administration of 0.6 mg/kg rocuronium with train-of-four stimulations in patients with type 2 diabetes mellitus (DM, N=14) and without diabetes mellitus (control, N=14) during isoflurane based general anesthesia. The onset time, clinical duration and recovery index of rocuronium were compared in the two groups.
RESULTS: The mean onset time (136 ± 40 vs 118 ± 20 s), clinical duration (51 ± 11 vs 48 ± 11 min) and recovery index (6.0 ± 2.5 vs 5.9 ± 1.4 min) of the neuromuscular block were not significantly different between the DM and control groups, respectively (p>0.05).
CONCLUSIONS: The present study has proven that the rocuronium-induced neuromuscular block was not affected in patients with type 2 diabetes mellitus during isoflurane based general anesthesia.

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