CASE REPORT   

European Journal of Oral and Maxillofacial Surgery 2019 April;3(1):17-20

DOI: 10.23736/S2532-3466.18.00149-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

IgG4-related sialadenitis of the right submandibular gland

Antonio DELL'AQUILA ¹ ✉, Annachiara SALVATO ¹, Gabriele VITIELLO ¹, Daniele SORANO ¹, Luigi VECCHIONE ², Graziella DI GREZIA ³

¹ Unit of Oral and Maxillofacial Surgery, Del Mare Hospital, ASL Napoli 1 Centro, Naples, Italy; ² Unit of Odontostomatology, Pellegrini Hospital, ASL Napoli 1 Centro, Naples, Italy; ³ Department of Radiology, G. Criscuoli Hospital, Sant’Angelo dei Lombardi, Avellino, Italy

IgG4-related sialadenitis (IgG4-RS) is a benign inflammatory autoimmune disease of the major salivary glands. Immunoglobulin G4-related diseases represent recently introduced multi-organ diseases that also involve the salivary glands. (IgG4-RS)/Küttner tumor is a fibroinflammatory process that characteristically involves the submandibular gland of patients with IgG4-related disease. Histologic examination is often important to make the diagnosis because of its nonspecific clinical and radiologic findings. Microscopically, (IgG4-RS) should be distinguished from other entities such as extranodal marginal zone lymphoma, Sjogren’s Syndrome, and lymphoepithelial sialadenitis. Clinicians and pathologists should consider the diagnosis of IgG4-RS/Küttner tumor in patients with elevated serum IgG4 level. Timely and accurate diagnosis is important for appropriate management.

KEY WORDS: Sialadenitis - Immunoglobulin G4-related disease - Mandibular neoplasms