Home > Riviste > International Angiology > Fascicoli precedenti > Articles online first > International Angiology 2022 Feb 09



Opzioni di pubblicazione
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca


Publication history
Per citare questo articolo



International Angiology 2022 Feb 09

DOI: 10.23736/S0392-9590.22.04754-X


lingua: Inglese

Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio predict in-hospital mortality in symptomatic but unruptured abdominal aortic aneurysm patients

Fernando GARAGOLI 1 , Norberto FIORINI 1, María N. PÉREZ 1, José M. RABELLINO 2, Juan VALLE RALEIGH 3, José G. CHAS 2, Vanesa DI CARO 2, Rodolfo PIZARRO 1, Ignacio M. BLURO

1 Department of Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; 2 Department of Interventional Radiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; 3 Department of Interventional Cardiology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina


BACKGROUND: Symptomatic but unruptured abdominal aortic aneurysm (AAA) is a potentially fatal disease since its etiopathogenesis, involving acute changes in the aortic wall, including inflammation, increasing the probability of impending rupture. The objective of the present study was to assess the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and the plateletto-lymphocyte ratio (PLR) in patients undergoing urgent symptomatic AAA repair.
METHODS: This was a retrospective study including 29 patients with symptomatic AAA repaired between 2011 and 2020. Both NLR and PLR were calculated on hospital admission prior to the intervention. The primary endpoint was in-hospital mortality, and the secondary endpoint included length of hospital stay and postoperative complications.
RESULTS: In-hospital mortality rate was 10.3%. The discriminatory performance to predict the primary endpoint was very good both for PLR [area under the ROC curve (AUC): 0.92 (95% confidence interval (CI): 0.82-1.00; p=0.02] and NLR [AUC: 0.88 (95% CI: 0.75-1.00); p=0.04]. The best cutoff point to predict in-hospital mortality was 185 for PLR (100% sensitivity and 85% specificity) and 6.4 for NLR (100% sensitivity and 77% specificity). The most frequent postoperative complication was acute kidney failure (37.9%). Both elevated PLR as NLR were significantly associated with acute kidney failure and multiorgan failure in the immediate postoperative period (p <0.01). None of the two ratios was associated with length of hospital stay (p=NS).
CONCLUSIONS: Both PLR and NLR are low-cost inflammatory markers widely available in every emergency department, with excellent performance to predict in-hospital mortality in patients undergoing symptomatic AAA repair. Patients with a PLR ≥185 and/or an NLR ≥6.4 could benefit from a “surveyed waiting conduct” improving the preoperative clinical condition prior to the intervention, or even considering endovascular repair.

KEY WORDS: Symptomatic abdominal aortic aneurysm; Inflammation; Neutrophils; Lymphocytes; Platelets

inizio pagina