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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2018 February;37(1):32-40

DOI: 10.23736/S0392-9590.17.03869-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

A comparative CFD analysis of common carotid fusiform aneurysm in canine models and vertebrobasilar fusiform aneurysm in human patients

Shewei GUO, Peng JIANG, Jian LIU, Xinjian YANG, Chuhan JIANG, Youxiang LI, Zhongxue WU

Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China


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BACKGROUND: Intracranial fusiform aneurysm (IFA) is a relatively uncommon subgroup of aneurysms. There are few reports that focus on the hemodynamics of IFA. In this study, we compared the hemodynamics of the canine model of common carotid fusiform aneurysm and vertebrobasilar fusiform aneurysms in human patients.
METHODS: Five male mongrel dogs were randomly chosen, and their unilateral common carotid artery (CCA) and external jugular vein were surgically exposed individually. The CCA was transected and interposed by the free segment of the external jugular vein through end-to-end anastomosis to form a fusiform aneurysm. 3D digital subtraction angiography data of each dog’s and five randomly chosen male patients’ vertebrobasilar fusiform aneurysms were obtained and then analyzed by computational fluid dynamics software. The morphological and hemodynamic parameters were compared between the dogs and the patients.
RESULTS: The morphological and hemodynamic parameters of the fusiform aneurysms were similar between the dogs and the patients. However, the hemodynamics was more complex in the patients.
CONCLUSIONS: The canine fusiform aneurysm model exhibits high similarity in morphology and hemodynamics with human patients’. Therefore, this model can be used to study the fluid-solid interaction in the aneurysm and to explore the underlying mechanisms of the development, rupture and occurrence of IFAs, which offers a pathophysiological tool to seek better treatments of IFAs.


KEY WORDS: Intracranial aneurysm - Animal models - Computational biology - Hydrodynamics - Common carotid artery

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Publication History

Issue published online: January 2, 2018
Article first published online: September 22, 2017
Manuscript accepted: September 7, 2017
Manuscript revised: July 27, 2017
Manuscript received: June 15, 2017

Per citare questo articolo

Guo S, Jiang P, Liu J, Yang X, Jiang C, Li Y, et al. A comparative CFD analysis of common carotid fusiform aneurysm in canine models and vertebrobasilar fusiform aneurysm in human patients. Int Angiol 2018;37:32-40. DOI: 10.23736/S0392-9590.17.03869-X

Corresponding author e-mail

wzx_neuroradiology@yahoo.com